ArticleBiomedical optics express2015
Design and performance of an ultra-flexible two-photon microscope for in vivo research.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 91 citations in OpenAlex.
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- Next-generation multicolor indicators for in vivo imaging of norepinephrine.Nature methods · 2026Article
- Pyrimidinergic calcium signaling links tubular metabolism to fibrosis in kidney disease.Nature communications · 2026Article
- Needle beam two-photon microscopy for simultaneous multiplane neural and vascular imaging in awake mice.PhotoniX · 2026Article
- Abundance-biased codon diversification prevents recombination in AAV production and ensures robust in vivo expression of functional FRET sensors.Communications biology · 2025Article
- Standardized measurements for monitoring and comparing multiphoton microscope systems.Nature protocols · 2025Review
- Integrated two-photon and optoacoustic microscopy for functional neuroimaging.Scientific reports · 2025Article
- Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke.Nature communications · 2025Article
- A low-cost FPGA-based approach for pile-up corrected high-speedNeurophotonics · 2025Article
- TWINKLE: An open-source two-photon microscope for teaching and research.bioRxiv : the preprint server for biology · 2025Article
- Article
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- Pia-FLOW: Deciphering hemodynamic maps of the pial vascular connectome and its response to arterial occlusion.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells.Nature communications · 2024Article
- Oligodendrocyte-axon metabolic coupling is mediated by extracellular KNature neuroscience · 2024Article
- Standardised Measurements for Monitoring and Comparing Multiphoton Microscope Systems.bioRxiv : the preprint server for biology · 2024Article
- Pain-induced adaptations in the claustro-cingulate pathway.Cell reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a cost-effective in vivo two-photon microscope with a highly flexible frontend for in vivo research. Our design ensures fast and reproducible access to the area of interest, including rotation of imaging plane, and maximizes space for auxiliary experimental equipment in the vicinity of the animal. Mechanical flexibility is achieved with large motorized linear stages that move the objective in the X, Y, and Z directions up to 130 mm. 360° rotation of the frontend (rotational freedom for one axis) is achieved with the combination of a motorized high precision bearing and gearing. Additionally, the modular design of the frontend, based on commercially available optomechanical parts, allows straightforward updates to future scanning technologies. The design exceeds the mobility of previous movable microscope designs while maintaining high optical performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.