ReviewWorld journal of gastrointestinal pathophysiology2015
Structural brain lesions in inflammatory bowel disease.
Review in World journal of gastrointestinal pathophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.Human brain mapping · 2023Article
- Article
- The relationship between Central Nervous System morphometry changes and key symptoms in Crohn's disease.Brain imaging and behavior · 2023Article
- Childhood Cerebral Vasculitis : A Multidisciplinary Approach.Clinical neuroradiology · 2023Review
- RORγt-Expressing Pathogenic CD4Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?Frontiers in aging neuroscience · 2022Review
- Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis.Journal of translational medicine · 2021Review
- Multiple Cerebral Infarction Associated with Cerebral Vasculitis in a Patient with Ulcerative Colitis.Internal medicine (Tokyo, Japan) · 2021Article
- Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases.International journal of molecular sciences · 2020Review
- Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke.Journal of neuroinflammation · 2018Review
- Trace Amine-Associated Receptors as Novel Therapeutic Targets for Immunomodulatory Disorders.Frontiers in pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system (CNS) complications or manifestations of inflammatory bowel disease deserve particular attention because symptomatic conditions can require early diagnosis and treatment, whereas unexplained manifestations might be linked with pathogenic mechanisms. This review focuses on both symptomatic and asymptomatic brain lesions detectable on imaging studies, as well as their frequency and potential mechanisms. A direct causal relationship between inflammatory bowel disease (IBD) and asymptomatic structural brain changes has not been demonstrated, but several possible explanations, including vasculitis, thromboembolism and malnutrition, have been proposed. IBD is associated with a tendency for thromboembolisms; therefore, cerebrovascular thromboembolism represents the most frequent and grave CNS complication. Vasculitis, demyelinating conditions and CNS infections are among the other CNS manifestations of the disease. Biological agents also represent a risk factor, particularly for demyelination. Identification of the nature and potential mechanisms of brain lesions detectable on imaging studies would shed further light on the disease process and could improve patient care through early diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.