ArticleJournal of pathogens2015
Protective Effects of Tinospora crispa Stem Extract on Renal Damage and Hemolysis during Plasmodium berghei Infection in Mice.
Article in Journal of pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Antimalarial Potency ofJournal of tropical medicine · 2026Article
- Pharmacological Effects of Biosynthesis Silver Nanoparticles UtilizingInternational journal of nanomedicine · 2024Article
- An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile ofPhytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2023Review
- Hepatoprotective activity ofFrontiers in cellular and infection microbiology · 2022Article
- Phytochemical Constituents, Antimalarial Efficacy, and Protective Effect ofPreventive nutrition and food science · 2020Article
- Antimalarial Activity ofJournal of tropical medicine · 2019Article
- Antimalarial Properties of Aqueous Crude Extracts ofJournal of tropical medicine · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal damage and hemolysis induced by malaria are associated with mortality in adult patients. It has been speculated that oxidative stress condition induced by malaria infection is involved in its pathology. Thus, we aimed to investigate the protective effects of Tinospora crispa stem extract on renal damage and hemolysis during Plasmodium berghei infection. T. crispa stem extract was prepared using hot water method and used for oral treatment in mice. Groups of ICR mice were infected with 1 × 10(7) parasitized erythrocytes of P. berghei ANKA by intraperitoneal injection and given the extracts (500, 1000, and 2000 mg/kg) twice a day for 4 consecutive days. To assess renal damage and hemolysis, blood urea nitrogen (BUN), creatinine, and hematocrit (%Hct) levels were then evaluated, respectively. Malaria infection resulted in renal damage and hemolysis as indicated by increasing of BUN and creatinine and decreasing of %Hct, respectively. However, protective effects on renal damage and hemolysis were observed in infected mice treated with these extracts at doses of 1000 and 2000 mg/kg. In conclusion, T. crispa stem extract exerted protective effects on renal damage and hemolysis induced by malaria infection. This plant may work as potential source in the development of variety of herbal formulations for malarial treatment.
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Registered trials
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