Evidence map›Paper›PMID 26600886›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada

The prognostic significance of preoperative leukocytosis and neutrophil-to-lymphocyte ratio in patients who underwent radical cystectomy for bladder cancer.

Cihat Ozcan, Onur Telli, Erdem Ozturk, Evren Suer, Mehmet Ilker Gokce, Omer Gulpinar, Derya Oztuna, Sumer Baltaci, Cagatay Gogus

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 6 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 6 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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  14. DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017
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  16. The neutrophil-to-lymphocyte ratio in clinical practice.Canadian Urological Association journal = Journal de l'Association des urologues du Canada
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Cihat OzcanAnkara University, School of Medicine, Department of Urology, Ankara, Turkey;
Onur TelliAnkara University, School of Medicine, Department of Urology, Ankara, Turkey;
Erdem OzturkAnkara University, School of Medicine, Department of Urology, Ankara, Turkey;
Evren SuerAnkara University, School of Medicine, Department of Urology, Ankara, Turkey;
Mehmet Ilker GokceAnkara University, School of Medicine, Department of Urology, Ankara, Turkey;
Omer GulpinarAnkara University, School of Medicine, Department of Urology, Ankara, Turkey;
Derya OztunaAnkara University, School of Medicine, Department of Biostatistics, Ankara, Turkey.
Sumer BaltaciAnkara University, School of Medicine, Department of Urology, Ankara, Turkey;
Cagatay GogusAnkara University, School of Medicine, Department of Urology, Ankara, Turkey;
Ankara University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe evaluated the prognostic effects of hematologic parameters of preoperative leukocytosis and neutrophil-to-lymphocyte ratio (NLR) in patients who underwent radical cystectomy for bladder cancer.

methodsWe retrospectively reviewed the medical records of 363 patients who underwent radical cystectomy for bladder cancer between January 1990 and June 2013. In total, 286 patients were included in the study. Age, gender, pathologic stage, lymph node involvement, preoperative hydronephrosis, histologic sub-type, surgical margin status, and lymphovascular invasion were recorded for each patient. Univariate and multivariate analysis were performed to determine the prognostic value of the preoperative clinical and laboratory parameters on disease-specific survival (DSS). Additionally, the correlation between leukocytosis and other factors were evaluated.

resultsAccording to the univariate analysis preoperative leukocytosis and NLR were detected as negative prognostic factors on DSS. Preoperative leukocytosis, NLR, stage, lymph node involvement, histologic subtype, grade and age were independent prognostic factors for DSS, on multivariate analysis. Patients with leukocytosis had higher stage, grade and lymphovascular invasion.

conclusionsInexpensive, reproducible, and readily available peripheral blood count components of white blood cell count and NLR were independent prognostic factors, which can stratify DSS risks in bladder cancer patients who underwent radical cystectomy.

Identifiers

PMID26600886
PMCPMC4639429
OpenAlexW2166490128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.