ArticleResearch in pharmaceutical sciences
The effect of hydroalcoholic extract of Ferula foetida stems on blood pressure and oxidative stress in dexamethasone-induced hypertensive rats.
Article in Research in pharmaceutical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Chemistry, Bioactivity, and Prediction of the Quality Marker (Q-Marker) ofMolecules (Basel, Switzerland) · 2023Review
- Therapeutic potential of Ferula foetida(Bunge) Regel on gastric ulcer model in rats.Environmental science and pollution research international · 2022Article
- Anti-inflammatory, anti-oxidant, and immunomodulatory activities of the genusIranian journal of basic medical sciences · 2021Review
- Effect of Selenium on Quantitative Structural Changes in Dexamethasone-Induced Immunodeficiency Rat Models.Iranian journal of medical sciences · 2021Article
- Antihypertensive Effects of Standardized Asafoetida: Effect on Hypertension Induced by Angiotensin II.Advanced biomedical research · 2020Article
- Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of theFrontiers in pharmacology · 2020Review
- Useful Medicinal Plants for Vision Impairment in Traditional Iranian Medicine.Galen medical journal · 2019Review
- The effects of hydroalcoholic extract ofResearch in pharmaceutical sciences · 2018Article
- Evaluation of fibrinolytic and antioxidant effects ofResearch in pharmaceutical sciences · 2017Article
- Protective effect ofResearch in pharmaceutical sciences · 2016Article
- Osteogenic induction of menstrual blood mesenchymal stem cell by differentAvicenna journal of phytomedicineArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferula foetida (Bunge) Regel. is one of the most widespread and important Ferula species with nutritional and medicinal applications. Some phytochemicals with helpful cardiovascular effects have been isolated from Ferula species. The present study was designed to evaluate the effects of hydroalcoholic extract of the stems of F. foetida in dexamethasone (Dex)-induced hypertension in rats. Hypertension was induced by subcutaneous injection of Dex (30 µg/kg) for 14 days. In a prevention study, rats received oral F. foetida extract (200, 400 and 800 mg/kg) for 4 days prior to Dex administration and during the test period (Days 1-18). In a treatment study, F. foetida extract was administered from day 8 to 14. Systolic blood pressure (SBP) was evaluated using tail-cuff method. The thymus weight was measured as an indicator of glucocorticoid activity. The hydrogen peroxide (H2O2) concentration and ferric reducing antioxidant power (FRAP) were measured in plasma samples. Dex-induced hypertensive rats showed significant increases in SBP and in plasma H2O2 and decreases in the body and thymus weights and in FRAP value (P<0.001). Administration of F. foetida extract significantly prevented and reversed hypertension at all doses. It also increased plasma FRAP value (P<0.001) but failed to decrease plasma H2O2 concentration. These results suggest antihypertensive and antioxidant effects of F. foetida stem extract in Dex-induced hypertension. More investigations are needed to elucidate the exact mechanism of antihypertensive effect of this traditional phytomedicine.
Indexed as
Identifiers
26600859PMC4623621W1837420290What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.