ArticleResearch in pharmaceutical sciences
Cytotoxicity and antiangiogenic effects of Rhus coriaria, Pistacia vera and Pistacia khinjuk oleoresin methanol extracts.
Article in Research in pharmaceutical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Physicochemical Characterisation and In Vitro Bioactivity of Sumac (Rhus coriaria)-Derived Exosome-Like Nanoparticles.Chemistry & biodiversity · 2026Article
- Chemical Composition and Antibacterial Activity of Essential Oils from Different Organs ofMolecules (Basel, Switzerland) · 2026Article
- Effects of Thyme, Cumin, and Sumac Extracts on Apoptosis and Paraptosis in Hepatocellular Carcinoma: Synergistic, Antagonistic, or Additive Properties.Food science & nutrition · 2025Article
- Donkey Gelatin and Keratin Nanofibers Loaded with Antioxidant Agents for Wound Healing Dressings.Gels (Basel, Switzerland) · 2024Article
- Rhus coriaria L. in tradition and innovation like natural dye.Scientific reports · 2024Article
- Review
- Potential anticancer activities of Rhus coriaria (sumac) extract against human cancer cell lines.Bioscience reports · 2021Article
- Pharmacological and Antioxidant Activities ofAntioxidants (Basel, Switzerland) · 2021Review
- Article
- Drying Effects on Phenolics and Free Radical-Scavenging Capacity ofMolecules (Basel, Switzerland) · 2019Article
- Article
- Synthesis and cytotoxic evaluation of some novel quinoxalinedione diarylamide sorafenib analogues.Research in pharmaceutical sciences · 2018Article
- Cytotoxic Effects and Anti-Angiogenesis Potential of Pistachio (Pistacia vera L.) Hulls against MCF-7 Human Breast Cancer Cells.Molecules (Basel, Switzerland) · 2018Article
- Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects.Frontiers in pharmacology · 2018Review
- Methanolic extract of Euchelus asper exhibits in-ovo anti-angiogenic and in vitro anti-proliferative activities.Biological research · 2017Article
- Human Adenocarcinoma Cell Line Sensitivity to Essential Oil Phytocomplexes from Pistacia Species: a Multivariate Approach.Molecules (Basel, Switzerland) · 2017Article
- Preparation and Characterization ofAdvanced pharmaceutical bulletin · 2017Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiogenesis, formation of new blood vessels, play an important role in some diseases such as cancer and its metastasis. Using angiogenesis inhibitors, therefore, is one of the ways for cancer treatment and prevention of metastasis. Medicinal plants have been shown to play a major role in the treatment of a variety of cancers. In this direction, cytotoxic and angiogenic effects of oleo gum resin extracts of Rhus coriaria, Pistacia vera and Pistacia khinjuk from Anacardiaceae family were studied. For IC50 values, cytotoxic effects of the plant extracts were evaluated at different concentrations (1, 10, 20, 40, 80,100 μg/ml) against human umbilical vein endothelial normal cell (HUVEC) and Y79 cell lines using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. In vitro tube formation on matrigel base was used to evaluate angiogenic effects in the presence of increasing concentrations (50, 100, 250 μg/ml) of the extracts. Vascular endothelium growth factor was used as angiogenesis stimulator. Gas chromatography results showed that α-pinene and β-pinene were the major essential oils constituents of all plant extracts. According to the MTT assay results, the R. coriaria resin extract was more cytotoxic than those of P. vera and P. khinjuk extracts (IC50, 9.1 ± 1.6 vs 9.8 ± 2.1 and 12.0 ± 1.9, respectively; P<0.05). Cytotoxic effects of all extracts against Y79 cell line was significantly higher than those of HUVEC used as a normal cell line (P<0.05). Tube formation assay also showed that extract of R. coriaria resin inhibited angiogenesis more significantly than other tested extracts (P<0.05). It could be concluded that R. coriaria resin extract possess cytotoxic effect and antiangiogenesis against cancer cells and as an anticancer natural product has a good potential for future studies.
Indexed as
Identifiers
26600850PMC4621630W1947379000What OpenQuestion holds
Registered trials
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