ArticleBreast care (Basel, Switzerland)2015
Radiotherapy Induces Development of Fragmented QRS in Patients with Breast Cancer.
Article in Breast care (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Radiotherapy-induced diffuse myocardial fibrosis in early-stage breast cancer patients - multimodality imaging study with six-year follow-up.Radiation oncology (London, England) · 2023Article
- Ventricular Arrhythmia in Cancer Patients: Mechanisms, Treatment Strategies and Future Avenues.Arrhythmia & electrophysiology review · 2023Review
- Article
- Conventional Treatments Cannot Improve Outcomes of Early-Stage Primary Breast Marginal Zone Lymphoma.Frontiers in oncology · 2020Article
- Electrocardiographic Characteristics of Breast Cancer Patients Treated with Chemotherapy.Cardiology research and practice · 2020Article
- Overexpression of CLEC3A promotes tumor progression and poor prognosis in breast invasive ductal cancer.OncoTargets and therapy · 2018Article
- QRS Fragmentation Patterns Representing Myocardial Scar Need to Be Separated from Benign Normal Variants: Hypotheses and Proposal for Morphology based Classification.Frontiers in physiology · 2016Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundMyocardial fibrosis is a well-known side effect of radiotherapy. Fragmented QRS (fQRS) has been shown to be a marker of myocardial fibrosis. We postulated that radiotherapy induces development of fQRS in breast cancer patients. PATIENTS AND
methodsBreast cancer patients receiving locoregional radiotherapy were enrolled. Patients who had fQRS on electrocardiography (ECG) before radiotherapy were excluded. All patients were revaluated for the development of fQRS at 1-year follow-up. An age-matched healthy group served as controls.
resultsA total of 52 breast cancer patients receiving locoregional radiotherapy were included (median age 49 years, interquartile range (IQR) 13). Of these, 19 (37%) had developed fQRS at 1-year follow-up. Compared with the control group, prevalence of fQRS was significantly higher in the irradiated group (37 vs. 12%; p < 0.002). Median total cardiac radiation dose was significantly higher in patients who had developed fQRS (5 Gy, IQR 5.2 vs. 1.7 Gy, IQR 4.4; p = 0.003). Cardiac radiation dose, entered either as a continuous variable (odds ratio (OR) 1.35, 95% confidence interval (CI) 104-1.74) or as a dichotomized variable (≥ 2.2 Gy, OR 6.48, 95% CI 1.47-28.61), was independently associated with the development of fQRS at 1-year follow-up.
conclusionRadiotherapy for breast cancer induces development of fQRS on ECG. Cardiac radiation dose is independently associated with the development of fQRS.
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