ReviewEXCLI journal2015
Osmoregulation in zebrafish: ion transport mechanisms and functional regulation.
Review in EXCLI journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 160 citations in OpenAlex.
- Serotonin stimulates proliferation of ionocytes via the 5-HT2A receptor in zebrafish larvae.The Journal of experimental biology · 2026Article
- Trade-offs between ionic regulation and hypoxia tolerance in zebrafish (Danio rerio) raised in a low pH environment.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Specialized gas-exchange endothelium of the zebrafish gill.bioRxiv : the preprint server for biology · 2025Article
- Effects of vitamin D supplementation under different salinities on hybrid red tilapia growth performance, hormonal profile and growth genes expression.Scientific reports · 2025Article
- Interactions Between Prolactin, Intracellular Signaling, and Possible Implications in the Contractility and Pathophysiology of Asthma.International journal of molecular sciences · 2025Review
- Transcriptomics and proteomics provide insights into the adaptative strategies of Tibetan naked carps (Gymnocypris przewalskii) to saline-alkaline variations.BMC genomics · 2025Article
- Evaluation of the Sedative Effect of Limonene to Reduce Stress During Transportation of Gilthead Seabream (Biology · 2025Article
- Paired and solitary ionocytes in the zebrafish olfactory epithelium.Chemical senses · 2025Article
- Metabolites Evaluation, Cytotoxicity, and Teratogenicity Analysis of Selected Medicinal Plants.Scientifica · 2025Article
- Anti-ovarian cancer migration and toxicity characteristics of a platinum(IV) pro-drug with axial HDAC inhibitor ligands in zebrafish models.Investigational new drugs · 2024Article
- Aryl phosphate ester-induced pericardial edema in zebrafish embryos is influenced by the ionic composition of exposure media.Aquatic toxicology (Amsterdam, Netherlands) · 2024Article
- Environmental and molecular control of tissue-specific ionocyte differentiation in zebrafish.Development (Cambridge, England) · 2024Article
- Endocrine control of gill ionocyte function in euryhaline fishes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- Ion uptake in naturally acidic water.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- Development of branchial ionocytes in embryonic and larval stages of cloudy catshark, Scyliorhinus torazame.Cell and tissue research · 2024Article
- Characterization of transcriptome changes in saline stress adaptation on Leuciscus merzbacheri using PacBio Iso-Seq and RNA-Seq.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Response of CRH system in brain and gill of marine medaka to seawater acidification.Fish physiology and biochemistry · 2024Article
- Deciphering the function of the fifth class of Gα proteins: regulation of ionic homeostasis as unifying hypothesis.Cellular and molecular life sciences : CMLS · 2024Article
- Environmental and molecular control of tissue-specific ionocyte differentiation in zebrafish.bioRxiv : the preprint server for biology · 2024Article
- Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fish, like mammals, have to maintain their body fluid ionic and osmotic homeostasis through sophisticated iono-/osmoregulation mechanisms, which are conducted mainly by ionocytes of the gill (the skin in embryonic stages), instead of the renal tubular cells in mammals. Given the advantages in terms of genetic database availability and manipulation, zebrafish is an emerging model for research into regulatory and integrative physiology. At least five types of ionocytes, HR, NaR, NCC, SLC26, and KS cells, have been identified to carry out Na(+) uptake/H(+) secretion/NH4 (+) excretion, Ca(2+) uptake, Na(+)/Cl(-) uptake, K(+) secretion, and Cl(-) uptake/HCO3 (-) secretion, respectively, through distinct sets of transporters. Several hormones, namely isotocin, prolactin, cortisol, stanniocalcin-1, calcitonin, endothelin-1, vitamin D, parathyorid hormone 1, catecholamines, and the renin-angiotensin-system, have been demonstrated to positively or negatively regulate ion transport through specific receptors at different ionocytes stages, at either the transcriptional/translational or posttranslational level. The knowledge obtained using zebrafish answered many long-term contentious or unknown issues in the field of fish iono-/osmoregulation. The homology of ion transport pathways and hormone systems also means that the zebrafish model informs studies on mammals or other animal species, thereby providing insights into related fields.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.