ReviewEXCLI journal2015
Neutrophil biology: an update.
Review in EXCLI journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Colchicine may become a new cornerstone therapy for coronary artery disease: a meta-analysis of randomized controlled trials.Clinical rheumatology · 2022Pooled it
- Neutrophil extracellular traps and metabolic reprogramming in renal cell carcinoma: implications for tumor progression and immune-based therapeutics.Cancer biology & medicine · 2025Review
- From pancreas to lungs: The role of immune cells in severe acute pancreatitis and acute lung injury.Immunity, inflammation and disease · 2024Review
- Platelets and platelet-derived vesicles as an innovative cellular and subcellular platform for managing multiple sclerosis.Molecular biology reports · 2023Review
- Evolving techniques for reducing phantom limb pain.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Hematological indices in the adult saudi population: Reference intervals by gender, age, and region.Frontiers in medicine · 2022Article
- Innate Immune Cells and Hypertension: Neutrophils and Neutrophil Extracellular Traps (NETs).Comprehensive Physiology · 2021Review
- Isolated Neutropenia/Benign Ethnic Neutropenia: A Common Clinical and Laboratory Finding in Southern and Western Saudi Arabia.International journal of general medicine · 2021Article
- A Proliferation-Inducing Ligand Regulation in Polymorphonuclear Neutrophils by Panax ginseng.Archivum immunologiae et therapiae experimentalis · 2020Article
- Model Particulate Drug Carriers Modulate Leukocyte Adhesion in Human Blood Flows.ACS biomaterials science & engineering · 2019Article
- Decreased integrity of exercise-induced plasma cell free nuclear DNA - negative association with the increased oxidants production by circulating phagocytes.Scientific reports · 2019Article
- Innate Immunity toJournal of immunology (Baltimore, Md. : 1950) · 2018Review
- Changes in Neutrophil Metabolism upon Activation and Aging.Inflammation · 2018Article
- Heterogeneity Among Neutrophils.Archivum immunologiae et therapiae experimentalis · 2018Review
- Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases.Frontiers in immunology · 2018Review
- Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin.Journal of immunology research · 2018Review
- Article
- Too much of a good thing: How modulating LTBSeminars in immunology · 2017Review
- Fungal Recognition and Host Defense Mechanisms.Microbiology spectrum · 2017Review
- Key mechanisms governing resolution of lung inflammation.Seminars in immunopathology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophil extracellular traps (NETs) are involved in bacterial killing as well as autoimmunity, because NETs contain proteases, bactericidal peptides, DNA and ribonucleoprotein. NETs are formed via a novel type of cell death called NETosis. NETosis is distinct from apoptosis, but it resembles necrosis in that both membranes are not intact so that they allow intracellular proteins to leak outside of the cells. Removal of NETs and neutrophils undergoing NETosis by phagocytes and its subsequent response are not completely clarified, as compared with the response after removal of either apoptotic or necrotic neutrophils by phagocytes. How neutrophil density in peripheral blood is kept within a certain range is important for health and disease. Although the studies on severe congenital neutropenia and benign ethnic neutropenia have provided unbiased views on it, the studies are rather limited to human neutropenia, and mice with a mutation of mouse counterpart gene often fail to exhibit neutropenia. Degranulation plays a critical role in bactericidal action. The recent studies revealed that it is also involved in immunomodulation, pain control and estrous cycle control. N1 and N2 are representative of neutrophil subpopulations. The dichotomy holds true in patients or mice with severe trauma or cancer, providing the basis of differential roles of neutrophils in diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.