ArticleEpidemiology (Cambridge, Mass.)2016
Long- and Short-term Exposure to Air Pollution and Inflammatory/Hemostatic Markers in Midlife Women.
Article in Epidemiology (Cambridge, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Susceptible window identification of the relationship between maternal ozone exposure and preterm birth.International health · 2026Pooled it
- A systematic review and meta-analysis of the stability of peripheral immune markers in healthy adults.Brain, behavior, and immunity · 2023Pooled it
- The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis.Environmental pollution (Barking, Essex : 1987) · 2020Pooled it
- Characteristics of cohort studies of long-term exposure to PMEnvironmental science and pollution research international · 2019Pooled it
- Metabolism-disrupting compounds and metabolic health during the menopausal transition: a narrative review.International journal of obesity (2005) · 2026Review
- PMEnvironment & health (Washington, D.C.) · 2026Article
- Inflammaging and Cardiovascular Risk in Old Women.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Review
- Air Pollution and Breast Cancer Incidence in the Multiethnic Cohort Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Article
- Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms.Fundamental research · 2025Review
- Longitudinal Exposure to Neighborhood Concentrated Poverty Contributes to Differences in Adiposity in Midlife Women.Journal of women's health (2002) · 2024Article
- Associations between short-term exposure to ambient air pollution and lung function in adults.Journal of exposure science & environmental epidemiology · 2024Article
- Analysis of gasoline-related pollutant exposures and risks in California between 1996 and 2014.Journal of exposure science & environmental epidemiology · 2024Article
- Duration-sensitive association between air pollution exposure and changes in cardiometabolic biomarkers: Evidence from a predominantly African American cohort.Environmental research · 2024Article
- Review
- Vitamin D3 regulates PM-driven primary human neutrophil inflammatory responses.Scientific reports · 2023Article
- Assessing the timing and the duration of exposure to air pollution on cardiometabolic biomarkers in patients suspected of coronary artery disease.Environmental research · 2023Article
- Particulate matter, traffic-related air pollutants, and circulating C-reactive protein levels: The Multiethnic Cohort Study.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Longitudinal profiles of neighborhood socioeconomic vulnerability influence blood pressure changes across the female midlife period.Health & place · 2023Article
- Assessment of Low-Level Air Pollution and Cardiovascular Incidence in Gdansk, Poland: Time-Series Cross-Sectional Analysis.Journal of clinical medicine · 2023Article
- Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England.PloS one · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundStudies have reported associations between long-term air pollution exposures and cardiovascular mortality. The biological mechanisms connecting them remain uncertain.
methodsWe examined associations of fine particles (PM2.5) and ozone with serum markers of cardiovascular disease risk in a cohort of midlife women. We obtained information from women enrolled at six sites in the multi-ethnic, longitudinal Study of Women's Health Across the Nation, including repeated measurements of high-sensitivity C-reactive protein, fibrinogen, tissue-type plasminogen activator antigen, plasminogen activator inhibitor type 1, and factor VIIc (factor VII coagulant activity). We obtained residence-proximate PM2.5 and ozone monitoring data for a maximum five annual visits, calculating prior year, 6-month, 1-month, and 1-day exposures and their relations to serum markers using longitudinal mixed models.
resultsFor the 2,086 women studied from 1999 to 2004, PM2.5 exposures were associated with all blood markers except factor VIIc after adjusting for age, race/ethnicity, education, site, body mass index, smoking, and recent alcohol use. Adjusted associations were strongest for prior year exposures for high-sensitivity C-reactive protein (21% increase per 10 μg/m³ PM2.5, 95% confidence interval [CI]: 6.6, 37), tissue-type plasminogen activator antigen (8.6%, 95% CI: 1.8, 16), and plasminogen activator inhibitor (35%, 95% CI: 19, 53). An association was also observed between year prior ozone exposure and factor VIIc (5.7% increase per 10 ppb ozone, 95% CI: 2.9, 8.5).
conclusionsOur findings suggest that prior year exposures to PM2.5 and ozone are associated with adverse effects on inflammatory and hemostatic pathways for cardiovascular outcomes in midlife women.
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