ArticlePloS one2015
Glutathione Peroxidase of Pennisetum glaucum (PgGPx) Is a Functional Cd2+ Dependent Peroxiredoxin that Enhances Tolerance against Salinity and Drought Stress.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- The family of glutathione peroxidase proteins and their role against biotic stress in plants: a systematic review.Frontiers in plant science · 2025Pooled it
- Cane water content regulates grapevine (Vitis vinifera L.) winter bud dormancy via ros homeostasis and antioxidant enzyme system.Molecular biology reports · 2026Article
- Differential gene reactions reveal drought response strategies in African acacias.The Plant journal : for cell and molecular biology · 2025Article
- The Glutathione Peroxidase Gene Family inAntioxidants (Basel, Switzerland) · 2025Article
- The role of pangenomics in orphan crop improvement.Nature communications · 2025Review
- Overexpression ofGenes · 2024Article
- Mitigating Salinity Stress in Quinoa (Plants (Basel, Switzerland) · 2023Article
- Real-time expression and in silico characterization of pea genes involved in salt and water-deficit stress.Molecular biology reports · 2023Article
- Milletdb: a multi-omics database to accelerate the research of functional genomics and molecular breeding of millets.Plant biotechnology journal · 2023Article
- Quantitative Proteomics and Functional Characterization Reveal That Glutathione Peroxidases Act as Important Antioxidant Regulators in Mulberry Response to Drought Stress.Plants (Basel, Switzerland) · 2022Article
- Identification of Candidate Genes Regulating Drought Tolerance in Pearl Millet.International journal of molecular sciences · 2022Article
- Article
- Physiological and Molecular Responses of 'Dusa' Avocado Rootstock to Water Stress: Insights for Drought Adaptation.Plants (Basel, Switzerland) · 2021Article
- Genome-Wide Characterization of Glutathione Peroxidase (GPX) Gene Family in Rapeseed (Antioxidants (Basel, Switzerland) · 2021Article
- Progressive Genomic Approaches to Explore Drought- and Salt-Induced Oxidative Stress Responses in Plants under Changing Climate.Plants (Basel, Switzerland) · 2021Review
- Identification of Glutathione Peroxidase Gene Family inFrontiers in plant science · 2021Article
- Comparative Transcriptomics and Co-Expression Networks Reveal Tissue- and Genotype-Specific Responses ofGenes · 2020Article
- ROS Homeostasis in Abiotic Stress Tolerance in Plants.International journal of molecular sciences · 2020Review
- A GMC Oxidoreductase GmcA Is Required for Symbiotic Nitrogen Fixation inFrontiers in microbiology · 2020Article
- iTRAQ-Based Protein Profiling and Biochemical Analysis of Two Contrasting Rice Genotypes Revealed Their Differential Responses to Salt Stress.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species (ROS) arise in the plant system due to inevitable influence of various environmental stimuli. Glutathione peroxidases are one of the important ROS scavengers inside the cell. A glutathione peroxidase (PgGPx) gene was previously found from Pennisetum glauccum abiotic stressed cDNA library. Enzyme kinetics data revealed that PgGPx possessed preference towards thioredoxin rather than glutathione as electron donor and thus belongs to the functional peroxiredoxin group. Moreover, its activity was found to be dependent on divalent cations, especially Cd2+ and homology model showed the presence of Cd2+ binding site in the protein. Site directed mutagenesis study of PgGPx protein revealed the vital role of two conserved Cysteine residues for its enzymatic activity and structural folding. Expression analysis suggested that PgGPx transcript is highly up-regulated in response to salinity and drought stresses. When expressed ectopically, PgGPx showed enhanced tolerance against multiple abiotic stresses in prokaryotic E. coli and model plant, rice. Transgenic rice plants showed lesser accumulation of MDA and H2O2; and higher accumulation of proline as compared to wild type (WT) plants in response to both salinity and drought stresses that clearly indicates suppression of lipid peroxidation and ROS generation in transgenic lines. Moreover, transgenic plants maintained better photosynthesis efficiency and higher level of antioxidant enzyme activity as compared to WT plants under stress conditions. These results clearly indicate the imperative role of PgGPx in cellular redox homeostasis under stress conditions, leading to the maintenance of membrane integrity and increased tolerance towards oxidative stress.
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