ArticlePsychoneuroendocrinology2016
Higher serum dehydroepiandrosterone sulfate protects against the onset of depression in the elderly: Findings from the English Longitudinal Study of Aging (ELSA).
Article in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Systematic review of sex differences in the relationship between hormones and depression in HIV.Psychoneuroendocrinology · 2022Pooled it
- Joint Trajectories of Physical Activity and Depressive Symptoms and Incident Cardiometabolic Multimorbidity: A Multi-Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Prediction of Clinically Significant Depressive Symptoms at 2-Year Follow-Up in Older Adults: Machine Learning Study Using the English Longitudinal Study of Ageing.JMIR formative research · 2026Article
- Are levels of DHEAS indicative of subjective health - results of the population-based longitudinal CARLA study.npj aging · 2026Article
- Effects of depression and cognitive impairment on increased risks of incident dementia: a prospective study from three elderly cohorts.Translational psychiatry · 2024Article
- Hair androgen concentrations and depressive disorders in adolescents from the general population.European child & adolescent psychiatry · 2023Observational
- ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses.Biomolecules · 2022Article
- Cerebral perfusion in depression: Relationship to sex, dehydroepiandrosterone sulfate and depression severity.NeuroImage. Clinical · 2021Article
- Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?The world journal of men's health · 2020Review
- Low Concentrations of Dehydroepiandrosterone Sulfate are Associated with Depression and Fatigue in Patients with Non-Small-Cell Lung Cancer After Chemotherapy.Neuropsychiatric disease and treatment · 2020Article
- DHEA Attenuates Microglial Activation via Induction of JMJD3 in Experimental Subarachnoid Haemorrhage.Journal of neuroinflammation · 2019Article
- The structure and predictive value of intrinsic capacity in a longitudinal study of ageing.BMJ open · 2019Article
- Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient.Burns & trauma · 2019Review
- Alterations in the steroid biosynthetic pathways in the human prefrontal cortex in mood disorders: A post-mortem study.Brain pathology (Zurich, Switzerland) · 2018Article
- DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway.Molecular psychiatry · 2018Article
- Androgen Regulation of the Mesocorticolimbic System and Executive Function.Frontiers in endocrinology · 2018Review
- Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults.Translational psychiatry · 2017Article
- Medical Yoga Therapy.Children (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Depression is one of the major causes of disability worldwide, but the complete etiology of depression is not fully understood. Dehydroepiandrosterone (DHEA) and its sulphated form DHEA(S) have been associated with mood and healthy aging. Associations with mental illness over the middle to late years of life have not yet been extensively investigated in large, western community-dwelling samples. The aim of this study was to investigate whether low DHEA(S) levels are associated with the development of depressive symptoms in a large longitudinal cohort study of older men and women. We assessed data from English Longitudinal Study of Aging (ELSA) to evaluate the association of DHEA(S) levels and depressive symptoms measured by Center for Epidemiologic Studies Scale (CES-D) at baseline (n=3083) and at 4-year follow-up (n=3009). At baseline, there was an inverse association between DHEA(S) and depressive symptoms (B=-0.252, p=0.014). Adjustments for physical illnesses, impairments in cognitive function and health behaviors abolished this association (p=0.109) at baseline. Decreased DHEA(S) levels at baseline also predicted incident depression at 4-year follow-up (B=-0.332, p<0.001). In conclusion, higher DHEA(S) levels were associated with reduced risk of developing depressive symptoms in both men and women.
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Registered trials
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