Evidence map›Paper›PMID 26599981›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2016

Can a simple test of functional capacity add to the clinical assessment of diabetes?

T Stewart, D G Caffrey, R H Gilman, S C Mathai, A Lerner, A Hernandez, M E Pinto, Y Huaylinos, L Cabrera, R A Wise and 2 more

Abstract read
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In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

T StewartDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
D G CaffreyDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
R H GilmanProgram in Disease Control and Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
S C MathaiDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
A LernerProgram in Disease Control and Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
A HernandezDivision of Endocrinology, Department of Medicine, Hospital Nacional Cayetano Heredia, Lima, Peru.
M E PintoDivision of Endocrinology, Department of Medicine, Hospital Nacional Cayetano Heredia, Lima, Peru.
Y HuaylinosDivision of Endocrinology, Department of Medicine, Hospital Nacional Cayetano Heredia, Lima, Peru.
L CabreraA.B. PRISMA, Lima, Peru.
R A WiseDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
J J MirandaDepartment of Medicine, School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID 0000-0002-4738-5468
W CheckleyDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USHospital Nacional Cayetano Heredia · PEUniversidad Peruana Cayetano Heredia · PEPrisma · PE

Funding

Acute Lung Injury: Application of Novel Approaches to Longitudinal Data AnalysisR00HL096955 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CHECKLEY, WILLIAM · 2011 to 2013
$723k
NHLBI NIH HHS HHSN268200900033CNHLBI NIH HHS R00 HL096955
6 · The paper itself

Abstract

aimTo identify impairment in functional capacity associated with complicated and non-complicated diabetes using the 6-min walk distance test.

methodsWe enrolled 111 adults, aged ≥40 years, with Type 2 diabetes from a hospital facility and 150 healthy control subjects of similar age and sex from a community site in Lima, Peru. All participants completed a 6-min walk test.

resultsThe mean age of the 261 participants was 58.3 years, and 43.3% were male. Among those with diabetes, 67 (60%) had non-complicated diabetes and 44 (40%) had complications such as peripheral neuropathy, retinopathy or nephropathy. The mean unadjusted 6-min walk distances were 376 m and 394 m in adults with and without diabetes complications, respectively, vs 469 m in control subjects (P<0.001). In multivariable regression, the subjects with diabetes complications walked 84 m less far (95% CI -104 to -63 m) and those without complications walked 60 m less far (-77 to -42 m) than did control subjects. When using HbA1c level as a covariate in multivariable regression, participants walked 13 m less far (-16.9 to -9.9 m) for each % increase in HbA1c .

conclusionsThe subjects with diabetes had lower functional capacity compared with healthy control subjects with similar characteristics. Differences in 6-min walk distance were even apparent in the subjects without diabetes complications. Potential mechanisms that could explain this finding are early cardiovascular disease or deconditioning.

Indexed as

Walk TestAgedCase-Control StudiesDiabetes Mellitus, Type 2Diabetic NephropathiesDiabetic NeuropathiesDiabetic RetinopathyFemaleGlycated HemoglobinHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisPeruGlycated Hemoglobinhemoglobin A1c protein, human

Identifiers

PMID26599981
PMCPMC4955604
OpenAlexW2179209189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.