ArticlePloS one2015
New Insight into the Time-Course of Motor and Sensory System Changes in Pain.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Association Between Nociplastic Pain Criteria and Clinical and Physiological Features in Temporomandibular Disorders: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Central and peripheral factors moderating pain effects on motor control and disability in chronic lumbosacral radicular pain.Journal of neuroengineering and rehabilitation · 2025Article
- Temporal changes in cortical sensory processing during the transition from acute to chronic low back pain.Pain reports · 2025Article
- Brain Circuits Involved in the Development of Chronic Musculoskeletal Pain: Evidence From Non-invasive Brain Stimulation.Frontiers in neurology · 2021Review
- Fear of movement is associated with corticomotor depression in response to acute experimental muscle pain.Experimental brain research · 2020Article
- Article
- Corticomotor excitability reduction induced by experimental pain remains unaffected by performing a working memory task as compared to staying at rest.Experimental brain research · 2019Article
- Article
- Differential Corticomotor Excitability Responses to Hypertonic Saline-Induced Muscle Pain in Forearm and Hand Muscles.Neural plasticity · 2018Article
- The side of chronic low back pain matters: evidence from the primary motor cortex excitability and the postural adjustments of multifidi muscles.Experimental brain research · 2017Article
- Effect of Experimental Cutaneous Hand Pain on Corticospinal Excitability and Short Afferent Inhibition.Brain sciences · 2016Article
- Pain-Induced changes in corticospinal excitability are associated with adaptive changes in muscle coordination.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPain-related interactions between primary motor (M1) and primary sensory (S1) cortex are poorly understood. In particular, the time-course over which S1 processing and corticomotor output are altered in association with muscle pain is unclear. We aimed to examine the temporal profile of altered processing in S1 and altered corticomotor output with finer temporal resolution than has been used previously.
methodsIn 10 healthy individuals we recorded somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) in separate sessions at multiple time-points before, during and immediately after pain induced by hypertonic saline infusion in a hand muscle, and at 15 and 25 minutes follow-up.
resultsParticipants reported an average pain intensity that was less in the session where SEPs were recorded (SEPs: 4.0 ± 1.6; MEPs: 4.9 ± 2.3). In addition, the time taken for pain to return to zero once infusion of hypertonic saline ceased was less for participants in the SEP session (SEPs: 4.7 ± 3.8 mins; MEPs 9.4 ± 7.4 mins). Both SEPs and MEPs began to reduce almost immediately after pain reached 5/10 following hypertonic saline injection and were significantly reduced from baseline by the second (SEPs) and third (MEPs) recording blocks during pain. Both parameters remained suppressed immediately after pain had resolved and at 15 and 25 minutes after the resolution of pain.
conclusionsThese data suggest S1 processing and corticomotor output may be co-modulated in association with muscle pain. Interestingly, this is in contrast to previous observations. This discrepancy may best be explained by an effect of the SEP test stimulus on the corticomotor pathway. This novel finding is critical to consider in experimental design and may be potentially useful to consider as an intervention for the management of pain.
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