Evidence map›Paper›PMID 26599599›Full record

ArticleMagnetic resonance in medicine2016

Diffusion MRI noise mapping using random matrix theory.

Jelle Veraart, Els Fieremans, Dmitry S Novikov

Abstract readEvaluation Study
In one paragraph

Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 504 papers.

0numbers the graph read from it
0cells of the map it votes in
504citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

504 citing papers in PubMed.

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  8. Gray Matter Microstructure Measured Using Diffusion Imaging as a Biomarker of Severity in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society · 2026
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444 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jelle VeraartCenter for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA. Jelle.veraart@nyumc.org.
Els FieremansCenter for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA.
Dmitry S NovikovCenter for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA.

Funding

PSYCHOSOCIAL COREP30AG008051 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHAO, YONGZHAO · 1990 to 2019
$36.1M
Mesoscopic Biomarkers of Neurodegeneration with Diffusion MRIR01NS088040 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS, NOVIKOV, DMITRY S · 2014 to 2023
$5.2M
NIA NIH HHS P30 AG008051NINDS NIH HHS R01 NS088040
6 · The paper itself

Abstract

purposeTo estimate the spatially varying noise map using a redundant series of magnitude MR images.

methodsWe exploit redundancy in non-Gaussian distributed multidirectional diffusion MRI data by identifying its noise-only principal components, based on the theory of noisy covariance matrices. The bulk of principal component analysis eigenvalues, arising due to noise, is described by the universal Marchenko-Pastur distribution, parameterized by the noise level. This allows us to estimate noise level in a local neighborhood based on the singular value decomposition of a matrix combining neighborhood voxels and diffusion directions.

resultsWe present a model-independent local noise mapping method capable of estimating the noise level down to about 1% error. In contrast to current state-of-the-art techniques, the resultant noise maps do not show artifactual anatomical features that often reflect physiological noise, the presence of sharp edges, or a lack of adequate a priori knowledge of the expected form of MR signal.

conclusionsSimulations and experiments show that typical diffusion MRI data exhibit sufficient redundancy that enables accurate, precise, and robust estimation of the local noise level by interpreting the principal component analysis eigenspectrum in terms of the Marchenko-Pastur distribution. Magn Reson Med 76:1582-1593, 2016. © 2015 International Society for Magnetic Resonance in Medicine.

Indexed as

AlgorithmsData Interpretation, StatisticalModels, StatisticalSignal-To-Noise RatioBrainComputer SimulationDiffusion Magnetic Resonance ImagingHumansImage Interpretation, Computer-AssistedPrincipal Component AnalysisReproducibility of ResultsSensitivity and Specificitydiffusion MRIMarchenko-Pasturnoiseprincipal component analysisRician

Identifiers

PMID26599599
PMCPMC4879661

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.