ArticleMagnetic resonance in medicine2016
Functional imaging of the nonhuman primate Placenta with endogenous blood oxygen level-dependent contrast.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Real-time fetal brain and placental T2* mapping at 0.55T MRI.Magnetic resonance in medicine · 2025Article
- Feasibility of multimodal magnetic resonance imaging to assess maternal hyperoxygenation in sheep pregnancy.The Journal of physiology · 2025Article
- Trophoblast Organoids: Capturing the Complexity of Early Placental Development In Vitro.Organoids · 2024Article
- Magnetic resonance imaging of placental intralobule structure and function in a preclinical nonhuman primate model†.Biology of reproduction · 2024Article
- Advanced magnetic resonance imaging detects altered placental development in pregnancies affected by congenital heart disease.Scientific reports · 2024Article
- Advanced magnetic resonance imaging detects altered placental development in pregnancies affected by congenital heart disease.Research square · 2024Article
- The human placenta project: Funded studies, imaging technologies, and future directions.Placenta · 2023Review
- Reliability and Feasibility of Low-Field-Strength Fetal MRI at 0.55 T during Pregnancy.Radiology · 2023Article
- A review of feto-placental vasculature flow modelling.Placenta · 2023Review
- Assessing within-subject rates of change of placental MRI diffusion metrics in normal pregnancy.Magnetic resonance in medicine · 2023Article
- Impaired placental hemodynamics and function in a non-human primate model of gestational protein restriction.Scientific reports · 2023Article
- Ferumoxytol dynamic contrast enhanced magnetic resonance imaging identifies altered placental cotyledon perfusion in rhesus macaques†.Biology of reproduction · 2022Article
- Chronic prenatal delta-9-tetrahydrocannabinol exposure adversely impacts placental function and development in a rhesus macaque model.Scientific reports · 2022Article
- Cardiac and placental imaging (CARP) in pregnancy to assess aetiology of preeclampsia.Placenta · 2022Article
- Volumetric Parameterization of the Placenta to a Flattened Template.IEEE transactions on medical imaging · 2022Article
- Observational
- Effects of early daily alcohol exposure on placental function and fetal growth in a rhesus macaque model.American journal of obstetrics and gynecology · 2022Article
- Article
- Observational
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo characterize spatial patterns of T2* in the placenta of the rhesus macaque (Macaca mulatta), to correlate these patterns with placental perfusion determined using dynamic contrast-enhanced MRI (DCE-MRI), and to evaluate the potential for using the blood oxygen level-dependent effect to quantify placental perfusion without the use of exogenous contrast reagent.
methodsMRI was performed on three pregnant rhesus macaques at gestational day 110. Multiecho spoiled gradient echo measurements were used to compute maps of T2*. Spatial maxima in these maps were compared with foci of early enhancement determined by DCE-MRI.
resultsLocal maxima in T2* maps were strongly correlated with spiral arteries identified by DCE-MRI, with mean spatial separations ranging from 2.34 to 6.11 mm in the three animals studied. Spatial patterns of R2* ( = 1/ T2*) within individual placental lobules can be quantitatively analyzed using a simple model to estimate fetal arterial oxyhemoglobin concentration [Hbo,f] and a parameter viPS/Φ, reflecting oxygen transport to the fetus. Estimated mean values of [Hbo,f] ranged from 4.25 mM to 4.46 mM, whereas viPS/Φ ranged from 2.80 × 10
conclusionsMaternal spiral arteries show strong spatial correlation with foci of extended T2* observed in the primate placenta. A simple model of oxygen transport accurately describes the spatial dependence of R2* within placental lobules and enables assessment of placental function and oxygenation without requiring administration of an exogenous contrast reagent. Magn Reson Med 76:1551-1562, 2016. © 2015 International Society for Magnetic Resonance in Medicine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.