ArticlePloS one2015
Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Targeting cardiac resident CCR2+ macrophage-secreted MCP-1 to attenuate inflammation after myocardial infarction.Acta biomaterialia · 2026Article
- Refining the Guinea Pig (Cavia porcellus) Cryo-Injury Model for Cardiac Regeneration and Functional Characterization.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Injection of Matrix Metalloproteinase-9 Leads to Ventricular Remodeling.Disease markers · 2022Article
- The Prominin-1-Derived Peptide Improves Cardiac Function Following Ischemia.International journal of molecular sciences · 2021Article
- NIPAM-based Microgel Microenvironment Regulates the Therapeutic Function of Cardiac Stromal Cells.ACS applied materials & interfaces · 2018Article
- Ataxia telangiectasia mutated kinase deficiency impairs the autophagic response early during myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2018Article
- Integrin β-3 is required for the attachment, retention and therapeutic benefits of human cardiospheres in myocardial infarction.Journal of cellular and molecular medicine · 2018Article
- Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction.ACS nano · 2017Article
- A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart.Tissue engineering. Part C, Methods · 2017Article
- Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome.Nature communications · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
aimsThe coronary artery ligation model in rodents mimics human myocardial infarction (MI). Normally mechanical ventilation and prolonged anesthesia period are needed. Recently, a method has been developed to create MI by popping-out the heart (without ventilation) followed by immediate suture ligation. Mortality is high due to the time-consuming suture ligation process while the heart is exposed. We sought to improve this method and reduce mortality by rapid coronary ligation using a surgical clip instead of a suture. METHODS AND
resultsMice were randomized into 3 groups: clip MI (CMI), suture MI (SMI), or sham (SHAM). In all groups, heart was manually exposed without intubation through a small incision on the chest wall. Unlike the conventional SMI method, mice in the CMI group received a metal clip on left anterior descending artery (LAD), quickly dispensed by an AutoSuture Surgiclip™. The CMI method took only 1/3 of ligation time of the standard SMI method and improved post-MI survival rate. TTC staining and Masson's trichrome staining revealed a similar degree of infarct size in the SMI and CMI groups. Echocardiograph confirmed that both SMI and CMI groups had a similar reduction of ejection fraction and fraction shortening over the time. Histological analysis showed that the numbers of CD68+ macrophages and apoptotic cells (TUNEL-positive) are indistinguishable between the two groups.
conclusionThis new method, taking only less than 3 minutes to complete, represents an efficient myocardial infarction model in rodents.
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