ArticleMuscle & nerve2016
Impact of expiratory strength training in amyotrophic lateral sclerosis.
Article in Muscle & nerve, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 41 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Measuring the Effects of a Music Therapy Protocol on Respiratory and Bulbar Functions of Patients With Early and Mid-stage Amyotrophic Lateral Sclerosis: Mixed Methods Single Case Study Series
Interventional Study of Expiratory Muscle Strength Training as a Treatment in Neuromuscular Disorders
Quantifying Fatigue of the Respiratory and Swallowing Musculature in Patients With Amyotrophic Lateral Sclerosis
Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS
Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The effect of breathing training on swallowing function in patients with neurogenic dysphagia: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- The effect of exercise intervention on amyotrophic lateral sclerosis: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- A Systematic Review of Rehabilitation for Corticobulbar Symptoms in Adults with Huntington's Disease.Journal of Huntington's disease · 2020Pooled it
- Respiratory muscle training in children and adults with neuromuscular disease.The Cochrane database of systematic reviews · 2019Pooled it
- Resistance exercise in early-stage ALS patients, ALSFRS-R, Sickness Impact Profile ALS-19, and muscle transcriptome: a pilot study.Scientific reports · 2024Trial
- Respiratory Strength Training in Amyotrophic Lateral Sclerosis: A Double-Blind, Randomized, Multicenter, Sham-Controlled Trial.Neurology · 2023Trial
- The level of effort, rather than muscle exercise intensity determines strength gain following a six-week training.Life sciences · 2017Trial
- Exploration of reliable assessment of respiratory function in amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Early Multidisciplinary Rehabilitation Improves Swallowing and Speech Function in a Patient With Amyotrophic Lateral Sclerosis.Clinical case reports · 2025Article
- Article
- Review
- Relationship between pulmonary, cough, and swallowing functions in individuals with amyotrophic lateral sclerosis.Muscle & nerve · 2024Article
- Improvement in Swallowing Function in Patients with Previous Irradiation for Nasopharyngeal Carcinoma by Expiratory Muscle Strength Training.Dysphagia · 2024Article
- Hypotussic cough in persons with dysphagia: biobehavioral interventions and pathways to clinical implementation.Frontiers in rehabilitation sciences · 2024Review
- Future Directions for Respiratory Muscle Training in Neuromuscular Disorders: A Scoping Review.Respiration; international review of thoracic diseases · 2024Article
- Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis.BMJ (Clinical research ed.) · 2023Review
- Review
- A meta-analysis of post-exercise outcomes in people with amyotrophic lateral sclerosis.eNeurologicalSci · 2023Review
- Dysphagia Advances in Head and Neck Cancer.Current otorhinolaryngology reports · 2023Review
- The role of lung volume recruitment therapy in neuromuscular disease: a narrative review.Frontiers in rehabilitation sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
introductionWe evaluated the feasibility and impact of expiratory muscle strength training (EMST) on respiratory and bulbar function in persons with amyotrophic lateral sclerosis (ALS).
methodsTwenty-five ALS patients participated in this delayed intervention open-label clinical trial. Following a lead-in period, patients completed a 5-week EMST protocol. Outcome measures included: maximum expiratory pressure (MEP); physiologic measures of swallow and cough; and penetration-aspiration scale (PAS) scores.
resultsOf participants who entered the active phase of the study (n = 15), EMST was well tolerated and led to significant increases in MEPs and maximum hyoid displacement during swallowing post-EMST (P < 0.05). No significant differences were observed for PAS scores or cough spirometry measures.
conclusionsEMST was feasible and well tolerated in this small cohort of ALS patients and led to improvements in expiratory force-generating pressures and swallow kinematics. Further investigation is warranted to confirm these preliminary findings. Muscle Nerve 54: 48-53, 2016.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.