Evidence map›Paper›PMID 26599156›Full record

ArticleMedical image analysis2015

High-throughput histopathological image analysis via robust cell segmentation and hashing.

Xiaofan Zhang, Fuyong Xing, Hai Su, Lin Yang, Shaoting Zhang

Open access · greenAbstract read
In one paragraph

Article in Medical image analysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 90 citations in OpenAlex.

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  8. AI in Medical Imaging Informatics: Current Challenges and Future Directions.IEEE journal of biomedical and health informatics · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiaofan ZhangDepartment of Computer Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Fuyong XingDepartment of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA.
Hai SuDepartment of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Lin YangDepartment of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Shaoting ZhangDepartment of Computer Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA. Electronic address: rutgers.shaoting@gmail.com.
University of Florida · USUniversity of North Carolina at Charlotte · US

Funding

Development and Dissemination of MuscleMiner: An Imaging Informatics Tool for MusR01AR065479 · NIAMS · UNIVERSITY OF FLORIDA · PI DING, MINGZHOU · 2014 to 2018
$1.8M
NIAMS NIH HHS R01 AR065479NIAMS NIH HHS R01 AR06547901A1
6 · The paper itself

Abstract

Computer-aided diagnosis of histopathological images usually requires to examine all cells for accurate diagnosis. Traditional computational methods may have efficiency issues when performing cell-level analysis. In this paper, we propose a robust and scalable solution to enable such analysis in a real-time fashion. Specifically, a robust segmentation method is developed to delineate cells accurately using Gaussian-based hierarchical voting and repulsive balloon model. A large-scale image retrieval approach is also designed to examine and classify each cell of a testing image by comparing it with a massive database, e.g., half-million cells extracted from the training dataset. We evaluate this proposed framework on a challenging and important clinical use case, i.e., differentiation of two types of lung cancers (the adenocarcinoma and squamous carcinoma), using thousands of lung microscopic tissue images extracted from hundreds of patients. Our method has achieved promising accuracy and running time by searching among half-million cells .

Indexed as

AdenocarcinomaCarcinoma, Squamous CellCell TrackingDiagnosis, DifferentialHigh-Throughput Screening AssaysHumansImage EnhancementImage Interpretation, Computer-AssistedLung NeoplasmsMicroscopyPattern Recognition, AutomatedReproducibility of ResultsSensitivity and SpecificityCell segmentationHashingHistopathological image analysisImage retrievalLarge-scale

Identifiers

PMID26599156
PMCPMC4679540
OpenAlexW2173930701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.