ArticlePloS one2015
RNA-Seq Analysis Reveals MAPKKK Family Members Related to Drought Tolerance in Maize.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Cloning and Functional Analysis of thePlants (Basel, Switzerland) · 2026Article
- Stress-responsive transcription factor families are key components of the core abiotic stress response in maize.G3 (Bethesda, Md.) · 2025Article
- Responses of maize roots, rhizosphere enzyme kinetics and prokaryote diversity to alternating precipitation: insights from a three-year field study.Annals of botany · 2025Article
- The integration of quantitative trait locus mapping and transcriptome studies reveals candidate genes for water stress response in St. Augustinegrass.BMC plant biology · 2025Article
- Genome-wide identification and unveiling the role of MAP kinase cascade genes involved in sugarcane response to abiotic stressors.BMC plant biology · 2025Article
- Genetic diversity and environmental adaptation in Ethiopian tef.G3 (Bethesda, Md.) · 2025Article
- A genome-wide association study identified SNP markers and candidate genes associated with morphometric fruit quality traits in mangoes.BMC genomics · 2025Article
- Identification of candidate genes for drought tolerance in soybean through QTL mapping and gene expression analysis.Frontiers in genetics · 2025Article
- Review
- Nanobiotechnology-mediated regulation of reactive oxygen species homeostasis under heat and drought stress in plants.Frontiers in plant science · 2024Review
- Comparative Transcriptome Analysis Reveals the Underlying Response Mechanism to Salt Stress in Maize Seedling Roots.Metabolites · 2023Article
- Genome-wide identification and characterization of the MAPKKK, MKK, and MPK families in Chinese elite maize inbred line Huangzaosi.The plant genome · 2022Article
- The maize single-nucleus transcriptome comprehensively describes signaling networks governing movement and development of grass stomata.The Plant cell · 2022Article
- Genome-Wide Identification of MAPK, MAPKK, and MAPKKK Gene Families inFrontiers in genetics · 2022Article
- ZmbHLH124 identified in maize recombinant inbred lines contributes to drought tolerance in crops.Plant biotechnology journal · 2021Article
- Plant Mitogen-Activated Protein Kinase Cascades in Environmental Stresses.International journal of molecular sciences · 2021Review
- Using single-plant-omics in the field to link maize genes to functions and phenotypes.Molecular systems biology · 2020Article
- Time Series RNA-seq in Pigeonpea Revealed the Core Genes in Metabolic Pathways under Aluminum Stress.Genes · 2020Article
- Genome-wide identification of MAPKKK genes and their responses to phytoplasma infection in Chinese jujube (Ziziphus jujuba Mill.).BMC genomics · 2020Article
- Dual RNA-seq reveals large-scale non-conserved genotype × genotype-specific genetic reprograming and molecular crosstalk in the mycorrhizal symbiosis.The ISME journal · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitogen-activated protein kinase (MAPK) cascade is an evolutionarily conserved signal transduction pathway that is involved in plant development and stress responses. As the first component of this phosphorelay cascade, mitogen-activated protein kinase kinase kinases (MAPKKKs) act as adaptors linking upstream signaling steps to the core MAPK cascade to promote the appropriate cellular responses; however, the functions of MAPKKKs in maize are unclear. Here, we identified 71 MAPKKK genes, of which 14 were novel, based on a computational analysis of the maize (Zea mays L.) genome. Using an RNA-seq analysis in the leaf, stem and root of maize under well-watered and drought-stress conditions, we identified 5,866 differentially expressed genes (DEGs), including 8 MAPKKK genes responsive to drought stress. Many of the DEGs were enriched in processes such as drought stress, abiotic stimulus, oxidation-reduction, and metabolic processes. The other way round, DEGs involved in processes such as oxidation, photosynthesis, and starch, proline, ethylene, and salicylic acid metabolism were clearly co-expressed with the MAPKKK genes. Furthermore, a quantitative real-time PCR (qRT-PCR) analysis was performed to assess the relative expression levels of MAPKKKs. Correlation analysis revealed that there was a significant correlation between expression levels of two MAPKKKs and relative biomass responsive to drought in 8 inbred lines. Our results indicate that MAPKKKs may have important regulatory functions in drought tolerance in maize.
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