Evidence map›Paper›PMID 26598954›Full record

ReviewCurrent opinion in anaesthesiology2016

Acute respiratory distress syndrome following cardiovascular surgery: current concepts and novel therapeutic approaches.

Sandra Hoegl, Bernhard Zwissler, Holger K Eltzschig, Christine Vohwinkel

Abstract readReview
In one paragraph

Review in Current opinion in anaesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sandra HoeglaOrgan Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado, USA bDepartment of Anesthesiology and Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, University Hospital, Ludwig-Maximilians-University, Munich, Germany cDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Bernhard Zwissler
Holger K Eltzschig
Christine Vohwinkel

Funding

Trangenic Mouse Breeding CoreP01HL114457 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHANG, YUJIN · 2013 to 2017
$10.0M
Extracellular Adenosine During Ventilator Induced Lung InjuryR01HL092188 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ELTZSCHIG, HOLGER K. · 2009 to 2013
$2.1M
Proton Pump Inhibitors for Perioperative Acute Kidney InjuryR01DK097075 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2013 to 2017
$1.7M
Hypoxia Inducible Factor in Acute Lung InjuryR01HL098294 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ELTZSCHIG, HOLGER K. · 2011 to 2014
$1.6M
Amphiregulin Signaling in Perioperative Cardio-ProtectionR01HL119837 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2014 to 2017
$1.5M
Alternative Mechanisms of Adenosine Receptor ActivationR01DK083385 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ELTZSCHIG, HOLGER K. · 2010 to 2013
$1.2M
NHLBI NIH HHS P01 HL114457NHLBI NIH HHS P0I-HL114457NHLBI NIH HHS R01 HL092188NHLBI NIH HHS R01-HL092188NHLBI NIH HHS R01 HL098294NHLBI NIH HHS R01-HL098294NHLBI NIH HHS R01 HL119837NHLBI NIH HHS R01-HL119837NIDDK NIH HHS R01 DK083385NIDDK NIH HHS R01 DK097075NIDDK NIH HHS R01-DK097075
6 · The paper itself

Abstract

purpose of reviewThis review gives an update on current treatment options and novel concepts on the prevention and treatment of the acute respiratory distress syndrome (ARDS) in cardiovascular surgery patients. RECENT

findingsThe only proven beneficial therapeutic options in ARDS are those that help to prevent further ventilator-induced lung injury, such as prone position, use of lung-protective ventilation strategies, and extracorporeal membrane oxygenation. In the future also new approaches like mesenchymal cell therapy, activation of hypoxia-elicited transcription factors or targeting of purinergic signaling may be successful outside the experimental setting. Owing to the so far limited treatment options, it is of great importance to determine patients at risk for developing ARDS already perioperatively. In this context, serum biomarkers and lung injury prediction scores could be useful. SUMMARY: Preventing ARDS as a severe complication in the cardiovascular surgery setting may help to reduce morbidity and mortality. As cardiovascular surgery patients are of greater risk to develop ARDS, preventive interventions should be implemented early on. Especially, use of low tidal volumes, avoiding of fluid overload and restrictive blood transfusion regimes may help to prevent ARDS.

Indexed as

Cardiovascular Surgical ProceduresHumansPostoperative ComplicationsRespiration, ArtificialRespiratory Distress SyndromeVentilator-Induced Lung Injury

Identifiers

PMID26598954
PMCPMC4689613

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.