ArticleHuman brain mapping2016
Hemodynamic response function abnormalities in schizophrenia during a multisensory detection task.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis on neural changes of cognitive training for mental disorders in executive function tasks: increase or decrease brain activation?BMC psychiatry · 2022Pooled it
- Reduced glymphatic clearance in early psychosis.Molecular psychiatry · 2025Article
- Towards whole brain mapping of the hemodynamic response function.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Multivariate Association Between Functional Connectivity Gradients and Cognition in Schizophrenia Spectrum Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Cognition is entangled with metabolism: relevance for resting-state EEG-fMRI.Frontiers in human neuroscience · 2023Article
- Beyond the Beta Rebound: Post-Task Responses in Oscillatory Activity follow Cessation of Working Memory Processes.NeuroImage · 2023Article
- A systematic review of the neural correlates of multisensory integration in schizophrenia.Schizophrenia research. Cognition · 2022Article
- Disrupted Intersubject Variability Architecture in Functional Connectomes in Schizophrenia.Schizophrenia bulletin · 2021Article
- From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum.Frontiers in aging neuroscience · 2021Review
- Differing functional mechanisms underlie cognitive control deficits in psychotic spectrum disorders.Journal of psychiatry & neuroscience : JPN · 2020Article
- Evidence for asymmetric inhibitory activity during motor planning phases of sensorimotor synchronization.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Changes in Hemodynamic Response Function Resulting From Chronic Alcohol Consumption.Alcoholism, clinical and experimental research · 2020Article
- Hemodynamic responses are abnormal in isolated cervical dystonia.Journal of neuroscience research · 2020Article
- Structural and Functional Features of Developing Brain Capillaries, and Their Alteration in Schizophrenia.Frontiers in cellular neuroscience · 2020Review
- Late fMRI Response Components Are Altered in Autism Spectrum Disorder.Frontiers in human neuroscience · 2020Article
- Disconnected and Hyperactive: A Replication of Sensorimotor Cortex Abnormalities in Patients With Schizophrenia During Proactive Response Inhibition.Schizophrenia bulletin · 2019Article
- Multimodal Neuroimaging in Schizophrenia: Description and Dissemination.Neuroinformatics · 2017Article
- Assessing dynamic functional connectivity in heterogeneous samples.NeuroImage · 2017Article
- Post-stimulus fMRI and EEG responses: Evidence for a neuronal origin hypothesised to be inhibitory.NeuroImage · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) of the blood oxygen level dependent (BOLD) response has commonly been used to investigate the neuropathology underlying cognitive and sensory deficits in patients with schizophrenia (SP) by examining the positive phase of the BOLD response, assuming a fixed shape for the hemodynamic response function (HRF). However, the individual phases (positive and post-stimulus undershoot (PSU)) of the HRF may be differentially affected by a variety of underlying pathologies. The current experiment used a multisensory detection task with a rapid event-related fMRI paradigm to investigate both the positive and PSU phases of the HRF in SP and healthy controls (HC). Behavioral results indicated no significant group differences during task performance. Analyses that examined the shape of the HRF indicated two distinct group differences. First, SP exhibited a reduced and/or prolonged PSU following normal task-related positive BOLD activation in secondary auditory and visual sensory areas relative to HC. Second, SP did not show task-induced deactivation in the anterior node of the default-mode network (aDMN) relative to HC. In contrast, when performing traditional analyses that focus on the positive phase, there were no group differences. Interestingly, the magnitude of the PSU in secondary auditory and visual areas was positively associated with the magnitude of task-induced deactivation within the aDMN, suggesting a possible common neural mechanism underlying both of these abnormalities (failure in neural inhibition). Results are consistent with recent views that separate neural processes underlie the two phases of the HRF and that they are differentially affected in SP. Hum Brain Mapp 37:745-755, 2016. © 2015 Wiley Periodicals, Inc.
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