Evidence map›Paper›PMID 26598750›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2016

Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study.

Maura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, Melinda L Irwin

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 25 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 25 syntheses or guidelines pooled it, 184 citations in OpenAlex.

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  5. Digital versus nondigital behavioral interventions on cardiovascular risk reduction: systematic review and meta-analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025
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  11. Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  12. Benefits of weight loss programs for breast cancer survivors: a systematic reviews and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  16. Virtual Care in Patients with Cancer: A Systematic Review.Current oncology (Toronto, Ont.) · 2021
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  17. Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maura HarriganMaura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD.
Brenda CartmelMaura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD.
Erikka LoftfieldMaura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD.
Tara SanftMaura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD.
Anees B ChagparMaura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD.
Yang ZhouMaura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD.
Mary PlaydonMaura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD.
Fangyong LiMaura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD.
Melinda L IrwinMaura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD. melinda.irwin@yale.edu.
National Cancer Institute · USYale University · US

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
NCATS NIH HHS UL1 TR000142NCI NIH HHS P30 CA016359NCI NIH HHS P30CA016359
6 · The paper itself

Abstract

purposeObesity is associated with a higher risk of breast cancer mortality. The gold standard approach to weight loss is in-person counseling, but telephone counseling may be more feasible. We examined the effect of in-person versus telephone weight loss counseling versus usual care on 6-month changes in body composition, physical activity, diet, and serum biomarkers.

methodsOne hundred breast cancer survivors with a body mass index ≥ 25 kg/m(2) were randomly assigned to in-person counseling (n = 33), telephone counseling (n = 34), or usual care (UC) (n = 33). In-person and telephone counseling included 11 30-minute counseling sessions over 6 months. These focused on reducing caloric intake, increasing physical activity, and behavioral therapy. Body composition, physical activity, diet, and serum biomarkers were measured at baseline and 6 months.

resultsThe mean age of participants was 59 ± 7.5 years old, with a mean BMI of 33.1 ± 6.6 kg/m(2), and the mean time from diagnosis was 2.9 ± 2.1 years. Fifty-one percent of the participants had stage I breast cancer. Average 6-month weight loss was 6.4%, 5.4%, and 2.0% for in-person, telephone, and UC groups, respectively (P = .004, P = .009, and P = .46 comparing in-person with UC, telephone with UC, and in-person with telephone, respectively). A significant 30% decrease in C-reactive protein levels was observed among women randomly assigned to the combined weight loss intervention groups compared with a 1% decrease among women randomly assigned to UC (P = .05).

conclusionBoth in-person and telephone counseling were effective weight loss strategies, with favorable effects on C-reactive protein levels. Our findings may help guide the incorporation of weight loss counseling into breast cancer treatment and care.

Indexed as

TelephoneWeight LossBiomarkers, TumorBody CompositionBreast NeoplasmsCounselingDietFemaleHumansMaleMiddle AgedMotor ActivityObesitySurvivorsBiomarkers, Tumor

Identifiers

PMID26598750
PMCPMC4872022
OpenAlexW2179951467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.