ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Genealogical correspondence of a forebrain centre implies an executive brain in the protostome-deuterostome bilaterian ancestor.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 63 citations in OpenAlex.
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- What do the mushroom bodies do for the insect brain? Twenty-five years of progress.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Model systems for discovering evolutionary singularity of bilaterian physiological regulation: lessons from studies on simple/primitive flatworms.Biophysics and physicobiology · 2024Article
- Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits.Acta neuropathologica communications · 2023Article
- Comparative biology of spatial navigation in three arachnid orders (Amblypygi, Araneae, and Scorpiones).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- Lipophorin receptors regulate mushroom body development and complex behaviors in Drosophila.BMC biology · 2022Article
- Contextual memory reactivation modulates CaScientific reports · 2022Article
- Neurotransmission and neuromodulation systems in the learning and memory network of Octopus vulgaris.Journal of morphology · 2022Article
- Exploring Higher-Order Conceptual Learning in an Arthropod with a Large Multisensory Processing Center.Insects · 2022Article
- Humans, fish, spiders and bees inherited working memory and attention from their last common ancestor.Frontiers in psychology · 2022Article
- Anatomy of the Nervous System inInsects · 2021Article
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- Transsynaptic mapping ofeLife · 2021Article
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- Ancestral regulatory mechanisms specify conserved midbrain circuitry in arthropods and vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Neural architecture and regeneration in the acoelProceedings. Biological sciences · 2020Article
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- Cephalopod Brains: An Overview of Current Knowledge to Facilitate Comparison With Vertebrates.Frontiers in physiology · 2018Review
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Orthologous genes involved in the formation of proteins associated with memory acquisition are similarly expressed in forebrain centres that exhibit similar cognitive properties. These proteins include cAMP-dependent protein kinase A catalytic subunit (PKA-Cα) and phosphorylated Ca(2+)/calmodulin-dependent protein kinase II (pCaMKII), both required for long-term memory formation which is enriched in rodent hippocampus and insect mushroom bodies, both implicated in allocentric memory and both possessing corresponding neuronal architectures. Antibodies against these proteins resolve forebrain centres, or their equivalents, having the same ground pattern of neuronal organization in species across five phyla. The ground pattern is defined by olfactory or chemosensory afferents supplying systems of parallel fibres of intrinsic neurons intersected by orthogonal domains of afferent and efferent arborizations with local interneurons providing feedback loops. The totality of shared characters implies a deep origin in the protostome-deuterostome bilaterian ancestor of elements of a learning and memory circuit. Proxies for such an ancestral taxon are simple extant bilaterians, particularly acoels that express PKA-Cα and pCaMKII in discrete anterior domains that can be properly referred to as brains.
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