ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
The molecular evolution of the vertebrate behavioural repertoire.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Evolutionary Trajectories of Consciousness: From Biological Foundations to Technological Horizons.Brain sciences · 2025Review
- Quantitative proteomics of dorsolateral prefrontal cortex reveals an early pattern of synaptic dysmaturation in children with idiopathic autism.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- From emotional signals to symbols.Frontiers in psychology · 2024Article
- Review
- Genetic Disruption of System xc-Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Towards the Idea of Molecular Brains.International journal of molecular sciences · 2021Review
- Continent-wide genomic signatures of adaptation to urbanisation in a songbird across Europe.Nature communications · 2021Article
- Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules.Nature communications · 2019Article
- Artificial selection on brain size leads to matching changes in overall number of neurons.Evolution; international journal of organic evolution · 2019Article
- Article
- The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system.Histochemistry and cell biology · 2019Article
- Evolutionary-developmental modeling of neurodiversity and psychopathology.The Behavioral and brain sciences · 2019Article
- Architecture of the Mouse Brain Synaptome.Neuron · 2018Article
- Expression properties exhibit correlated patterns with the fate of duplicated genes, their divergence, and transcriptional plasticity in Saccharomycotina.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Regulatory remodeling in the allo-tetraploid frog Xenopus laevis.Genome biology · 2017Article
- Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders.Scientific reports · 2017Article
- Amplification of mGluThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Recent advances in understanding the roles of whole genome duplications in evolution.F1000Research · 2017Review
- Introduction to 'Homology and convergence in nervous system evolution'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Synapse molecular complexity and the plasticity behaviour problem.Brain and neuroscience advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
How the sophisticated vertebrate behavioural repertoire evolved remains a major question in biology. The behavioural repertoire encompasses the set of individual behavioural components that an organism uses when adapting and responding to changes in its external world. Although unicellular organisms, invertebrates and vertebrates share simple reflex responses, the fundamental mechanisms that resulted in the complexity and sophistication that is characteristic of vertebrate behaviours have only recently been examined. A series of behavioural genetic experiments in mice and humans support a theory that posited the importance of synapse proteome expansion in generating complexity in the behavioural repertoire. Genome duplication events, approximately 550 Ma, produced expansion in the synapse proteome that resulted in increased complexity in synapse signalling mechanisms that regulate components of the behavioural repertoire. The experiments demonstrate the importance to behaviour of the gene duplication events, the diversification of paralogues and sequence constraint. They also confirm the significance of comparative proteomic and genomic studies that identified the molecular origins of synapses in unicellular eukaryotes and the vertebrate expansion in proteome complexity. These molecular mechanisms have general importance for understanding the repertoire of behaviours in different species and for human behavioural disorders arising from synapse gene mutations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.