ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Loss of neurogenesis in Hydra leads to compensatory regulation of neurogenic and neurotransmission genes in epithelial cells.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Conditional Senescence and Longevity Mechanisms in Early-Branching Metazoans: Insights fromCurrent issues in molecular biology · 2026Article
- Engineered Living Systems With Self-Organizing Neural Networks: From Anatomy to Behavior and Gene Expression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Novel technologies uncover novel 'anti'-microbial peptides inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- On being a Hydra with, and without, a nervous system: what do neurons add?Animal cognition · 2023Review
- The transcription factor Zic4 promotes tentacle formation and prevents epithelial transdifferentiation inScience advances · 2022Article
- A novel regulatory gene promotes novel cell fate by suppressing ancestral fate in the sea anemoneProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Studying Stem Cell Biology in Intact and Whole-Body Regenerating Hydra by Flow Cytometry.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Cellular, Metabolic, and Developmental Dimensions of Whole-Body Regeneration inCold Spring Harbor perspectives in biology · 2021Review
- The structural basis of Bcl-2 mediated cell death regulation in hydra.The Biochemical journal · 2020Article
- Deficient autophagy in epithelial stem cells drives aging in the freshwater cnidarianDevelopment (Cambridge, England) · 2020Article
- The polymorphism of Hydra microsatellite sequences provides strain-specific signatures.PloS one · 2020Article
- Transgenesis in Hydra to characterize gene function and visualize cell behavior.Nature protocols · 2019Article
- Loss of Neurogenesis in Aging Hydra.Developmental neurobiology · 2019Article
- An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra.Nature communications · 2019Article
- Inherency of Form and Function in Animal Development and Evolution.Frontiers in physiology · 2019Review
- Functional studies on the role of Notch signaling in Hydractinia development.Developmental biology · 2017Article
- Generation and Long-term Maintenance of Nerve-free Hydra.Journal of visualized experiments : JoVE · 2017Article
- Article
- Introduction to 'Homology and convergence in nervous system evolution'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Diversity of Cnidarian Muscles: Function, Anatomy, Development and Regeneration.Frontiers in cell and developmental biology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Hydra continuously differentiates a sophisticated nervous system made of mechanosensory cells (nematocytes) and sensory-motor and ganglionic neurons from interstitial stem cells. However, this dynamic adult neurogenesis is dispensable for morphogenesis. Indeed animals depleted of their interstitial stem cells and interstitial progenitors lose their active behaviours but maintain their developmental fitness, and regenerate and bud when force-fed. To characterize the impact of the loss of neurogenesis in Hydra, we first performed transcriptomic profiling at five positions along the body axis. We found neurogenic genes predominantly expressed along the central body column, which contains stem cells and progenitors, and neurotransmission genes predominantly expressed at the extremities, where the nervous system is dense. Next, we performed transcriptomics on animals depleted of their interstitial cells by hydroxyurea, colchicine or heat-shock treatment. By crossing these results with cell-type-specific transcriptomics, we identified epithelial genes up-regulated upon loss of neurogenesis: transcription factors (Dlx, Dlx1, DMBX1/Manacle, Ets1, Gli3, KLF11, LMX1A, ZNF436, Shox1), epitheliopeptides (Arminins, PW peptide), neurosignalling components (CAMK1D, DDCl2, Inx1), ligand-ion channel receptors (CHRNA1, NaC7), G-Protein Coupled Receptors and FMRFRL. Hence epitheliomuscular cells seemingly enhance their sensing ability when neurogenesis is compromised. This unsuspected plasticity might reflect the extended multifunctionality of epithelial-like cells in early eumetazoan evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.