ArticleProceedings of the National Academy of Sciences of the United States of America2015
Tracking the origins of Yakutian horses and the genetic basis for their fast adaptation to subarctic environments.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70 citing papers in PubMed, 176 citations in OpenAlex.
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- Historical and contemporary genomes of an endangered rodent reveal shifts in environmentally associated genes.Science advances · 2026Article
- Review: Genomic insights into the adaptive traits and stress resistance in modern horses.Stress biology · 2026Review
- Mitochondrial DNA reveals high maternal diversity within a weak breed structure in native Kazakhstani horses.Frontiers in genetics · 2026Article
- Late Iron Age and Roman equine breeding north of the Alps: Genetic insights and cultural implications.iScience · 2025Article
- High-quality, haplotype-resolved reference genomes of the Dutch warmblood horse and Friesian horse using trio binning.BMC genomics · 2025Article
- The genomic history of Iberian horses since the last Ice Age.Nature communications · 2025Article
- Positive selection on rare variants of IGF1R and BRD4 underlying the cold adaptation of wild boar.Genetics, selection, evolution : GSE · 2025Article
- Transcriptomic Analysis of Skin Tissue Reveals Molecular Mechanisms of Thermal Adaptation in Cold-Exposed Lambs.Animals : an open access journal from MDPI · 2025Article
- Genomic Insights into Post-Domestication Expansion and Selection of Body Size in Ponies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genome-wide scan for selection signatures reveals novel insights into the adaptive capacity characteristics in three Chinese cattle breeds.BMC genomics · 2025Article
- Genome-wide selection signatures address trait specific candidate genes in cattle indigenous to arid regions of India.Animal biotechnology · 2024Article
- An endothelial regulatory module links blood pressure regulation with elite athletic performance.PLoS genetics · 2024Article
- Nutritional Quality and Socio-Ecological Benefits of Mare Milk Produced under Grazing Management.Foods (Basel, Switzerland) · 2024Review
- Modeling Climate Change Effects on Genetic Diversity of an Endangered Horse Breed Using Canonical Correlations.Animals : an open access journal from MDPI · 2024Article
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- The Characteristics, Distribution, Function, and Origin of Alternative Lateral Horse Gaits.Animals : an open access journal from MDPI · 2023Review
- Genetic diversity and signatures of selection in four indigenous horse breeds of Iran.Heredity · 2023Article
- Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
40 authors at 17 institutions in 9 countries.
Funding
Abstract
Yakutia, Sakha Republic, in the Siberian Far East, represents one of the coldest places on Earth, with winter record temperatures dropping below -70 °C. Nevertheless, Yakutian horses survive all year round in the open air due to striking phenotypic adaptations, including compact body conformations, extremely hairy winter coats, and acute seasonal differences in metabolic activities. The evolutionary origins of Yakutian horses and the genetic basis of their adaptations remain, however, contentious. Here, we present the complete genomes of nine present-day Yakutian horses and two ancient specimens dating from the early 19th century and ∼5,200 y ago. By comparing these genomes with the genomes of two Late Pleistocene, 27 domesticated, and three wild Przewalski's horses, we find that contemporary Yakutian horses do not descend from the native horses that populated the region until the mid-Holocene, but were most likely introduced following the migration of the Yakut people a few centuries ago. Thus, they represent one of the fastest cases of adaptation to the extreme temperatures of the Arctic. We find cis-regulatory mutations to have contributed more than nonsynonymous changes to their adaptation, likely due to the comparatively limited standing variation within gene bodies at the time the population was founded. Genes involved in hair development, body size, and metabolic and hormone signaling pathways represent an essential part of the Yakutian horse adaptive genetic toolkit. Finally, we find evidence for convergent evolution with native human populations and woolly mammoths, suggesting that only a few evolutionary strategies are compatible with survival in extremely cold environments.
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