Evidence map›Paper›PMID 26598612›Full record

ReviewThe Journal of cell biology2015

The multifaceted roles of the HORMA domain in cellular signaling.

Scott C Rosenberg, Kevin D Corbett

Abstract readReview
In one paragraph

Review in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Human Autophagy Core Complexes.Annual review of biochemistry · 2026
    Review
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  6. Review
  7. Article
  8. Article
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  11. Review
  12. p31International journal of molecular sciences · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. eLife · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Scott C RosenbergLudwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093.
Kevin D CorbettLudwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093 Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093 kcorbett@ucsd.edu.

Funding

Molecular mechanisms of chromosome organization and recombination control by the meiotic chromosome axis.R01GM104141 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CORBETT, KEVIN DANIEL · 2013 to 2021
$3.1M
NIGMS NIH HHS R01 GM104141NIGMS NIH HHS R01GM104141
6 · The paper itself

Abstract

The HORMA domain is a multifunctional protein-protein interaction module found in diverse eukaryotic signaling pathways including the spindle assembly checkpoint, numerous DNA recombination/repair pathways, and the initiation of autophagy. In all of these pathways, HORMA domain proteins occupy key signaling junctures and function through the controlled assembly and disassembly of signaling complexes using a stereotypical "safety belt" peptide interaction mechanism. A recent explosion of structural and functional work has shed new light on these proteins, illustrating how strikingly similar structural mechanisms give rise to radically different functional outcomes in each family of HORMA domain proteins.

Indexed as

Signal TransductionAnimalsAutophagyDNA-Binding ProteinsDNA-Directed DNA PolymeraseHumansMad2 ProteinsM Phase Cell Cycle CheckpointsProtein Interaction Domains and MotifsSaccharomyces cerevisiae ProteinsStructural Homology, ProteinDNA-Binding ProteinsDNA-Directed DNA PolymeraseHOP1 protein, S cerevisiaeMad2 ProteinsREV7 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID26598612
PMCPMC4657174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.