Evidence map›Paper›PMID 26598611›Full record

ArticleThe Journal of cell biology2015

Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell.

Marisa M Faraldo, Marina A Glukhova

Open access · hybridAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. iScience · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marisa M FaraldoInstitut Curie, PSL Research University, F-75248 Paris, France Centre National de la Recherche Scientifique, UMR144, F-75248 Paris, France Institut National de la Santé et de la Recherche Médicale, F-75013 Paris, France.
Marina A GlukhovaInstitut Curie, PSL Research University, F-75248 Paris, France Centre National de la Recherche Scientifique, UMR144, F-75248 Paris, France Institut National de la Santé et de la Recherche Médicale, F-75013 Paris, France Marina.Glukhova@curie.fr.
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue, Tosoni et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505037) report that cell fate determinant and tumor suppressor Numb imposes asymmetric cell divisions in mammary stem cells by regulating p53. Numb thereby restricts mammary stem cell expansion and controls the proliferation and lineage-specific characteristics of their progeny.

Indexed as

Cell Self RenewalAnimalsEpithelial CellsFemaleMembrane ProteinsNerve Tissue ProteinsTumor Suppressor Protein p53Membrane ProteinsNerve Tissue ProteinsTumor Suppressor Protein p53

Identifiers

PMID26598611
PMCPMC4657175
OpenAlexW2173618122

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.