ArticleThe EMBO journal2016
Fundamental physical cellular constraints drive self-organization of tissues.
Article in The EMBO journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Muscle fibre denervation in ageing.Clinical science (London, England : 1979) · 2026Review
- Geometric ordering in bacterial communities.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Reticulate leaf venation in Pilea peperomioides is a Voronoi diagram.Nature communications · 2026Article
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- Thin Cells of Polymer-Modified Liquid Crystals Described by Voronoi Diagrams.Materials (Basel, Switzerland) · 2025Article
- Article
- Local and global changes in cell density induce reorganisation of 3D packing in a proliferating epithelium.Development (Cambridge, England) · 2024Article
- Evolving topological order in the postnatal visceral pleura.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Marked irregular myofiber shape is a hallmark of human skeletal muscle ageing and is reversed by heavy resistance training.Journal of cachexia, sarcopenia and muscle · 2024Article
- CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia.Cell reports methods · 2023Article
- Tissues as networks of cells: towards generative rules of complex organ development.Journal of the Royal Society, Interface · 2023Review
- Implications of different membrane compartmentalization models in particle-basedRoyal Society open science · 2023Article
- The impact of cell size on morphogen gradient precision.Development (Cambridge, England) · 2023Article
- Article
- Geometric and network organization of visceral organ epithelium.Frontiers in network physiology · 2023Article
- Entropy as a Geometrical Source of Information in Biological Organizations.Entropy (Basel, Switzerland) · 2022Article
- Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering.Gels (Basel, Switzerland) · 2022Review
- Avalanches during epithelial tissue growth; Uniform Growth and a drosophila eye disc model.PLoS computational biology · 2022Article
- Soft Statistical Mechanics for Biology.Methods in molecular biology (Clifton, N.J.) · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Morphogenesis is driven by small cell shape changes that modulate tissue organization. Apical surfaces of proliferating epithelial sheets have been particularly well studied. Currently, it is accepted that a stereotyped distribution of cellular polygons is conserved in proliferating tissues among metazoans. In this work, we challenge these previous findings showing that diverse natural packed tissues have very different polygon distributions. We use Voronoi tessellations as a mathematical framework that predicts this diversity. We demonstrate that Voronoi tessellations and the very different tissues analysed share an overriding restriction: the frequency of polygon types correlates with the distribution of cell areas. By altering the balance of tensions and pressures within the packed tissues using disease, genetic or computer model perturbations, we show that as long as packed cells present a balance of forces within tissue, they will be under a physical constraint that limits its organization. Our discoveries establish a new framework to understand tissue architecture in development and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.