Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2015
High-Quality Foster Care Mitigates Callous-Unemotional Traits Following Early Deprivation in Boys: A Randomized Controlled Trial.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00747396 (The Bucharest Early Intervention Project), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Bucharest Early Intervention Project: Effects of Early Psychosocial Deprivation on Mental Health in Adolescence
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Early deprivation alters structural brain development from middle childhood to adolescence.Science advances · 2022Trial
- Autonomic reactivity to social rejection, peer difficulties, and the buffering effects of adolescent friendships following early psychosocial deprivation.Emotion (Washington, D.C.) · 2022Trial
- Heightened sensitivity to the caregiving environment during adolescence: implications for recovery following early-life adversity.Journal of child psychology and psychiatry, and allied disciplines · 2021Trial
- Psychiatric outcomes following severe deprivation in early childhood: Follow-up of a randomized controlled trial at age 16.Journal of consulting and clinical psychology · 2020Trial
- A prospective longitudinal study of Reactive Attachment Disorder following early institutional care: considering variable- and person-centered approaches.Attachment & human development · 2019Trial
- Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial.The Journal of pediatrics · 2018Trial
- Early deprivation disruption of associative learning is a developmental pathway to depression and social problems.Nature communications · 2018Trial
- Conflict resolution dynamics with stable caregivers confer resilience for youth exposed to early caregiving-related adversity.Development and psychopathology · 2025Article
- Econeurobiology and brain development in children: key factors affecting development, behavioral outcomes, and school interventions.Frontiers in public health · 2024Review
- Childhood Experiences of Alternative Care and Callousness/Unemotionality: A Conceptual Model, Scoping Review, and Research Agenda.Clinical child and family psychology review · 2023Article
- Overlapping brain correlates of superior cognition among children at genetic risk for Alzheimer's disease and/or major depressive disorder.Scientific reports · 2023Article
- Impact of dimensions of early adversity on adult health and functioning: A 2-decade, longitudinal study.Development and psychopathology · 2022Article
- Parenting in the Context of the Child: Genetic and Social Processes.Monographs of the Society for Research in Child Development · 2022Article
- Early life adoption shows rearing environment supersedes transgenerational effects of paternal stress on aggressive temperament in the offspring.Translational psychiatry · 2021Article
- Callous-unemotional traits and reduced default mode network connectivity within a community sample of children.Development and psychopathology · 2021Article
- Development and Examination of the Reactive Attachment Disorder and Disinhibited Social Engagement Disorder Assessment Interview.Assessment · 2020Article
- Autonomic nervous system activity and callous-unemotional traits in physically maltreated youth.Child abuse & neglect · 2020Article
- Friendship and social functioning following early institutional rearing: The role of ADHD symptoms.Development and psychopathology · 2019Article
- Maternal depressive symptoms, self-focus, and caregiving behavior.Journal of affective disorders · 2018Article
- Maternal sensitivity to distress, attachment and the development of callous-unemotional traits in young children.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveCallous-unemotional (CU) traits in childhood are a developmental precursor to psychopathy, yet the origins and etiology of CU traits are not known. We examined CU traits among 12-year-old children exposed to severe early deprivation and evaluated whether a high-quality foster care intervention mitigated the development of high levels of CU traits.
methodParticipants were from the Bucharest Early Intervention Project, a randomized controlled trial of foster care for children in institutions. Children were recruited from institutions in Bucharest, Romania, along with age- and sex-matched children who were never institutionalized. Children raised in institutional settings were randomized (mean age = 22 months) to either a foster care group (n = 68) or a care-as-usual group (n = 68). CU traits were assessed at age 12.75 years in available participants from the randomized trial (n = 95) and children who were never institutionalized (n = 50).
resultsChildren who experienced institutional rearing as young children had significantly higher levels of CU traits in early adolescence compared to children who were never institutionalized. Intent-to-treat analysis indicated that, among boys, CU traits were significantly lower among those who received the foster care intervention compared to those randomized to care as usual. Caregiver responsiveness to distress, but not caregiver warmth, mediated the intervention effect on CU traits in boys.
conclusionThese findings provide the first evidence to date that psychosocial intervention can prevent the onset of CU traits. Although severe early deprivation predicted higher levels of CU traits, high-quality foster care that emphasized responsive caregiving reduced the impact of deprivation on CU trait development for boys. CLINICAL TRIAL REGISTRATION INFORMATION: The Bucharest Early Intervention Project; http://clinicaltrials.gov; NCT00747396.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.