Trial reportPediatrics2015
Stochastic Resonance Effects on Apnea, Bradycardia, and Oxygenation: A Randomized Controlled Trial.
Trial report in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Body positioning for spontaneously breathing preterm infants with apnoea.The Cochrane database of systematic reviews · 2017Pooled it
- Simulated kangaroo care in very preterm infants does not reduce physiological instability: the COSYBABY randomised controlled cross-over trial.Frontiers in pediatrics · 2025Article
- Apnea of Prematurity and Oxidative Stress: Potential Implications.Antioxidants (Basel, Switzerland) · 2024Review
- Sensory stimulation for apnoea mitigation in preterm infants.Pediatric research · 2022Review
- Vibroacoustic Study in the Neonatal Ward.Healthcare (Basel, Switzerland) · 2022Article
- The effect of sensory stimulation on apnea of prematurity.Journal of Taibah University Medical Sciences · 2022Article
- Treating Apnea of Prematurity.Cureus · 2022Review
- Stabilizing breathing pattern using local mechanical vibrations: comparison of deterministic and stochastic stimulations in rodent models of apnea of prematurity.Biomedical engineering letters · 2021Article
- Predicting apneic events in preterm infants using cardio-respiratory and movement features.Computer methods and programs in biomedicine · 2021Article
- Simultaneous Heart Rate Variability and Electroencephalographic Monitoring in Children in the Emergency Department.Journal of child & adolescent trauma · 2021Article
- Sensory Stimulation in the NICU Environment: Devices, Systems, and Procedures to Protect and Stimulate Premature Babies.Children (Basel, Switzerland) · 2021Review
- High variability in nurses' tactile stimulation methods in response to apnoea of prematurity-A neonatal manikin study.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Intermittent Hypoxemia in Preterm Infants.Clinics in perinatology · 2019Review
- Article
- The effect of mechanical or electrical stimulation on apnea length in mice.Biomedical engineering letters · 2018Article
- Effect of Tactile Stimulation on Termination and Prevention of Apnea of Prematurity: A Systematic Review.Frontiers in pediatrics · 2018Article
- Predicting Bradycardia in Preterm Infants Using Point Process Analysis of Heart Rate.IEEE transactions on bio-medical engineering · 2017Article
- Impact of Caffeine Boluses and Caffeine Discontinuation on Apnea and Hypoxemia in Preterm Infants.Journal of caffeine research · 2017Article
- Improving Neonatal Care with Technology.Frontiers in pediatrics · 2017Article
- Vibrotactile stimulation: A non-pharmacological intervention for opioid-exposed newborns.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the effect of stochastic resonance (SR) stimulation on preterm infant oxygen desaturation, bradycardia, and apnea events. We hypothesized that SR stimulation will reduce these events.
methodsThis was a randomized crossover study conducted from April 2012 to July 2014. Eligible preterm infants were not receiving ventilation support and had at least 1 clinically documented apnea, bradycardia, and/or oxygen desaturation event. The 3 outcome variables were as follows: oxygen desaturation, bradycardia, and apnea events. Infants received up to two 3- or 4-hour intervention periods of 30-minute alternating intervals of SR stimulation and no SR stimulation. The first intervention period was randomly assigned to begin with SR stimulation either on or off, whereas the next intervention period automatically began with the opposite on/off state. We compared the SR stimulation "on" periods with the SR stimulation "off" periods with each infant serving as his or her own control.
resultsThe sample consisted of 36 infants with a mean (±SD) gestational age of 30.5 ± 3 weeks and a birth weight of 1409 ± 450 g. SR stimulation decreased the number of apneic events by 50%. SR stimulation ameliorated every aspect of clinically significant oxygen desaturation events, with a 20% to 35% decrease in the number, duration, and intensity of oxygen desaturation events when SR stimulation was on. Also, SR stimulation produced a nearly 20% reduction in the intensity of bradycardia events.
conclusionsSR stimulation may be a noninvasive and nonpharmacologic treatment option for apnea, oxygen desaturation, and some aspects of bradycardia in premature infants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.