ArticleClinics (Sao Paulo, Brazil)2015
Effects of estrogen on functional and neurological recovery after spinal cord injury: An experimental study with rats.
Article in Clinics (Sao Paulo, Brazil), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Tibolone Improves Motor Recovery and Regulates Neuroinflammation and Gliosis in a Model of Traumatic Spinal Cord Injury.International journal of molecular sciences · 2025Article
- Enhancing Functional Recovery After Spinal Cord Injury Through Neuroplasticity: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Evaluating Sex Steroid Hormone Neuroprotection in Spinal Cord Injury in Animal Models: Is It Promising in the Clinic?Biomedicines · 2024Review
- The MYC axis in advanced prostate cancer is impacted through concurrent targeting of ERβ and AR using a novel ERβ-selective ligand alongside Enzalutamide.bioRxiv : the preprint server for biology · 2023Article
- Tibolone Improves Locomotor Function in a Rat Model of Spinal Cord Injury by Modulating Apoptosis and Autophagy.International journal of molecular sciences · 2023Article
- The Limited Effects of Estradiol Administration Immediately after Spinal Cord Injury.Puerto Rico health sciences journal · 2023Article
- The comparative effects of estrogen and tacrolimus on crushed sciatic nerve regeneration in male mice: functional and histopathological evaluation.Veterinary research forum : an international quarterly journal · 2022Article
- Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats.Frontiers in pharmacology · 2022Article
- Acute Dose-Dependent Neuroprotective Effects of Poly(pro-17β-estradiol) in a Mouse Model of Spinal Contusion Injury.ACS chemical neuroscience · 2021Article
- Time-to-treatment window and cross-sex potential of βToxicology and applied pharmacology · 2021Article
- Standardization of an experimental model of intradural injection after spinal cord injury in rats.Clinics (Sao Paulo, Brazil) · 2021Article
- Metabotropic glutamate receptor subtype 5 (mGluPhysiology & behavior · 2020Article
- Evaluation of the effects of erythropoietin and interleukin-6 in rats submitted to acute spinal cord injury.Clinics (Sao Paulo, Brazil) · 2019Article
- Combined effects of rat Schwann cells and 17β-estradiol in a spinal cord injury model.Metabolic brain disease · 2018Article
- Granulocyte Colony-Stimulating Factor Combined with Methylprednisolone Improves Functional Outcomes in Rats with Experimental Acute Spinal Cord Injury.Clinics (Sao Paulo, Brazil) · 2018Article
- Hormonal therapy in traumatic spinal cord injury.American journal of translational research · 2017Review
- Neuroprotective effects of estrogen in CNS injuries: insights from animal models.Neuroscience and neuroeconomics · 2017Article
- Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery.Neural regeneration research · 2016Review
- Effects of ganglioside G(M1) and erythropoietin on spinal cord lesions in rats: functional and histological evaluations.Clinics (Sao Paulo, Brazil) · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the functional and histological effects of estrogen as a neuroprotective agent after a standard experimentally induced spinal cord lesion.
methodsIn this experimental study, 20 male Wistar rats were divided into two groups: one group with rats undergoing spinal cord injury (SCI) at T10 and receiving estrogen therapy with 17-beta estradiol (4mg/kg) immediately following the injury and after the placement of skin sutures and a control group with rats only subjected to SCI. A moderate standard experimentally induced SCI was produced using a computerized device that dropped a weight on the rat's spine from a height of 12.5 mm. Functional recovery was verified with the Basso, Beattie and Bresnahan scale on the 2nd, 7th, 14th, 21st, 28th, 35th and 42nd days after injury and by quantifying the motor-evoked potential on the 42nd day after injury. Histopathological evaluation of the SCI area was performed after euthanasia on the 42nd day.
resultsThe experimental group showed a significantly greater functional improvement from the 28th to the 42nd day of observation compared to the control group. The experimental group showed statistically significant improvements in the motor-evoked potential compared with the control group. The results of pathological histomorphometry evaluations showed a better neurological recovery in the experimental group, with respect to the proportion and diameter of the quantified nerve fibers.
conclusionsEstrogen administration provided benefits in neurological and functional motor recovery in rats with SCI beginning at the 28th day after injury.
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