Evidence map›Paper›PMID 26598080›Full record

ArticleClinics (Sao Paulo, Brazil)2015

Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women.

Camila Borges Martins de Oliveira, Cássio Cardoso-Filho, Leonardo Silveira Bossi, Gustavo Jacob Lourenço, Maria Salete Costa-Gurgel, Carmen Silvia Passos Lima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Association of genetic predisposition studies inSaudi journal of biological sciences · 2024
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  2. Role ofInternational journal of reproductive biomedicine · 2022
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  7. Association of CytochromeFrontiers in public health · 2018
    Article
  8. Genomic Disparities in Breast Cancer Among Latinas.Cancer control : journal of the Moffitt Cancer Center · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Camila Borges Martins de OliveiraDepartamento de Clênica Médica, Faculdade de Ciências Médicas, Universidade de Campinas, Campinas, SP, Brazil.
Cássio Cardoso-FilhoCentro de Assistência Integral è Saúde da Mulher, Universidade de Campinas, Campinas, SP, Brazil.
Leonardo Silveira BossiCentro de Assistência Integral è Saúde da Mulher, Universidade de Campinas, Campinas, SP, Brazil.
Gustavo Jacob LourençoDepartamento de Clênica Médica, Faculdade de Ciências Médicas, Universidade de Campinas, Campinas, SP, Brazil.
Maria Salete Costa-GurgelCentro de Assistência Integral è Saúde da Mulher, Universidade de Campinas, Campinas, SP, Brazil.
Carmen Silvia Passos LimaDepartamento de Clênica Médica, Faculdade de Ciências Médicas, Universidade de Campinas, Campinas, SP, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe examined the influence of CYP1A1 A4889G and T6235C polymorphisms on the risk of sporadic breast cancer.

methodsDNA from 742 sporadic breast cancer patients and 742 controls was analyzed using the polymerase chain reaction, followed by the restriction fragment length polymorphism technique.

resultsMore patients had the CYP1A1 4889AG+GG genotype compared to controls (29.0% versus 23.2%, p=0.004). The G allele carriers had a 1.50-fold increased risk (95% CI: 1.14-1.97) of sporadic breast cancer compared to the other study participants. The frequency of the 4889AG+GG genotype among the Caucasian patients was higher than in the non-Caucasian patients (30.4% versus 20.2%, p=0.03) and controls (30.4% versus 23.2%, p=0.002). Caucasians and G allele carriers had a 1.61-fold increased risk (95% CI: 1.20-2.15) of sporadic breast cancer compared to other subjects. The CYP1A1 4889AG+GG genotype was more common among patients with a younger median age at first full-term pregnancy than among controls (33.8% versus 23.2%, p=0.001) and subjects whose first full-term pregnancies occurred at an older age (33.8% versus 26.1%, p=0.03). Women with the CYP1A1 4889AG+GG genotype and earlier first full-term pregnancies had a 1.87-fold (95% CI: 1.32-2.67) increased risk of sporadic breast cancer compared to the other study participants. Excess CYP1A1 4889AG+GG (39.8% versus27.1%, p=0.01) and 6235TC+CC (48.4% versus 35.9%, p=0.02) genotypes were also observed in patients with grade I and II tumors compared to patients with grade III tumors and controls (39.8% versus 23.2%, p=0.04; 48.4% versus 38.6%, p=0.04). The G and C allele carriers had a 2.44-fold (95% CI: 1.48-4.02) and 1.67-fold (95% CI: 1.03-2.69) increased risk, respectively, of developing grade I and II tumors compared to other subjects.

conclusionsThe CYP1A1 A4889G and T6235C polymorphisms may alter the risk of sporadic breast cancer in Brazilian women.

Indexed as

Polymorphism, GeneticAdultAgedAged, 80 and overBrazilBreast NeoplasmsCytochrome P-450 CYP1A1FemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMiddle AgedPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPregnancyCytochrome P-450 CYP1A1

Identifiers

PMID26598080
PMCPMC4602382
OpenAlexW2252475886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.