Evidence map›Paper›PMID 26598068›Full record

ArticleMolecular psychiatry2016

Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate.

C A Mastronardi, E Pillai, D A Pineda, A F Martinez, F Lopera, J I Velez, J D Palacio, H Patel, S Easteal, M T Acosta and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  2. Article
  3. Review
  4. Attention-deficit/hyperactive disorder updates.Frontiers in molecular neuroscience · 2022
    Review
  5. Article
  6. Brain sciences · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

C A MastronardiGenomics and Predictive Medicine, Genome Biology Department, John Curtin School of Medical Research, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, Australia.
E PillaiGenomics and Predictive Medicine, Genome Biology Department, John Curtin School of Medical Research, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, Australia.
D A PinedaGroup of Neurosciences, University of Antioquia, Medellin, Colombia.
A F MartinezMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
F LoperaGroup of Neurosciences, University of Antioquia, Medellin, Colombia.
J I VelezGenomics and Predictive Medicine, Genome Biology Department, John Curtin School of Medical Research, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, Australia.
J D PalacioGroup of Neurosciences, University of Antioquia, Medellin, Colombia.
H PatelGenomics and Predictive Medicine, Genome Biology Department, John Curtin School of Medical Research, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, Australia.
S EastealNational Center for Indigenous Genomics, Genome Biology Department, John Curtin School of Medical Research, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, Australia.
M T AcostaMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
F X CastellanosThe NYU Child Study Center at NYU Langone Medical Center, New York, NY, US and Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, US.
M MuenkeMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
M Arcos-BurgosGenomics and Predictive Medicine, Genome Biology Department, John Curtin School of Medical Research, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, Australia.

Funding

Genetic Analysis of Attention Deficit Hyperactivity DisorderZIAHG000175 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI SHAW, PHILIP · 2009 to 2025
$13.4M
Genetics of Attention Deficit Hyperactivity DisorderZ01HG000175 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI MUENKE, MAXIMILIAN · 2000 to 2008
$2.6M
Intramural NIH HHS Z01 HG000175
6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurodevelopmental disorder with serious long-term repercussions. Despite being one of the most common cognitive disorders, the clinical diagnosis of ADHD is based on subjective assessments of perceived behaviors. Endophenotypes (neurobiological markers that cosegregate and are associated with an illness) are thought to provide a more powerful and objective framework for revealing the underlying neurobiology than syndromic psychiatric classification. Here, we present the results of applying genetic linkage and association analyses to neuropsychological endophenotypes using microsatellite and single nucleotide polymorphisms. We found several new genetic regions linked and/or associated with these endophenotypes, and others previously associated to ADHD, for example, loci harbored in the LPHN3, FGF1, POLR2A, CHRNA4 and ANKFY1 genes. These findings, when compared with those linked and/or associated to ADHD, suggest that these endophenotypes lie on shared pathways. The genetic information provided by this study offers a novel and complementary method of assessing the genetic causes underpinning the susceptibility to behavioral conditions and may offer new insights on the neurobiology of the disorder.

Indexed as

AdolescentAdultAgedAged, 80 and overAttention Deficit Disorder with HyperactivityChildCognition DisordersColombiaEndophenotypesEthnicityFemaleGenetic Association StudiesGenetic LinkageGenetic Predisposition to DiseaseHumansMale

Identifiers

PMID26598068
PMCPMC4879118

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.