ArticleNeuro-oncology2016
Imaging and extent of surgical resection predict risk of meningioma recurrence better than WHO histopathological grade.
Article in Neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- The dural tail in intracranial meningioma: Heads up or tail down? A systematic review of the literature.Neurosurgical review · 2025Pooled it
- Bone Tumor Microenvironment Is Associated with Meningioma Enlargement and Inflammatory Transcriptional States: A Candidate Role for Macrophage-Derived IL-1β.Biomedicines · 2026Article
- Non-invasive Prediction of Meningioma Tumor Grade by Quantification of Shape-based Radiomics Features and Surface Regularity.Clinical neuroradiology · 2026Article
- Downregulation of sialyl-transferases and their role in malignant meningioma cells.Biomedical reports · 2026Article
- Review
- Identification of key elements in MRI reporting of intracranial meningiomas based on a nationwide survey of clinical experts in Germany.Scientific reports · 2025Article
- AOpen life sciences · 2025Article
- Retrospective analysis of recurrence patterns and clinical outcomes in grade I-III meningiomas after surgery.Surgical neurology international · 2025Article
- The dural attachment length predict prognosis in patients with recurrent meningiomas.Neurosurgical review · 2024Article
- Single versus multiple reoperations for recurrent intracranial meningiomas.Journal of neuro-oncology · 2024Article
- Topographic Patterns of Intracranial Meningioma Recurrences-Systematic Review with Clinical Implication.Cancers · 2024Review
- Atypical meningiomas compared to other WHO Grade 2 meningiomas: Histological features and prognosis.Neurosciences (Riyadh, Saudi Arabia) · 2024Article
- Location pattern of recurrence of fully resected grade 1 meningiomas.Acta neurochirurgica · 2023Article
- Meningioma in the elderly.Neuro-oncology advances · 2023Article
- The Role of Pre-Operative MRI for Prediction of High-Grade Intracranial Meningioma: A Retrospective Study.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Prognosis and histology of sporadic synchronous and metachronous meningiomas and comparative analyses with singular lesions.Neurosurgical review · 2023Article
- Sporadic multiple intracranial meningioma does not infer worse patient outcomes: results from a case control study.Journal of neuro-oncology · 2023Article
- Case Report: Recurrent meningioma with multiple metastases.Frontiers in oncology · 2023Article
- Meningioma and Other Meningeal Tumors.Advances in experimental medicine and biology · 2023Article
- Advances in Central Nervous System Tumor Classification.Advances in experimental medicine and biology · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRisk stratification of meningiomas by histopathological grade alone does not reliably predict which patients will progress/recur after treatment. We sought to determine whether preoperative imaging and clinical characteristics could predict histopathological grade and/or improve prognostication of progression/recurrence (P/R).
methodsWe retrospectively reviewed preoperative MR and CT imaging features of 144 patients divided into low-grade (2007 WHO grade I; n = 118) and high-grade (2007 WHO grades II/III; n = 26) groups that underwent surgery between 2002 and 2013 (median follow-up of 49 months).
resultsMultivariate analysis demonstrated that the risk factors most strongly associated with high-grade histopathology were male sex, low apparent diffusion coefficient (ADC), absent calcification, and high peritumoral edema. Remarkably, multivariate Cox proportional hazards analysis demonstrated that, in combination with extent of resection, ADC outperformed WHO histopathological grade for predicting which patients will suffer P/R after initial treatment. Stratification of patients into 3 risk groups based on non-Simpson grade I resection and low ADC as risk factors correlated with the likelihood of P/R (P < .001). The high-risk group (2 risk factors; n = 39) had a 45% cumulative incidence of P/R, whereas the low-risk group (0 risk factors; n = 31) had no P/R events at 5 years after treatment. Independent of histopathological grade, high-risk patients who received adjuvant radiotherapy had a lower 5-year crude rate of P/R than those without (17% vs 59%; P = .04).
conclusionsPatients with non-Simpson grade I resection and low ADC meningiomas are at significantly increased risk of P/R and may benefit from adjuvant radiotherapy and/or additional surgery.
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