ArticleScientific reports2015
Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 84 citations in OpenAlex.
- Article
- Lgr5+ ductal cells of von Ebner's glands: Candidate stem cells for turnover of posterior tongue taste buds.PloS one · 2026Article
- Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages.Nature communications · 2025Article
- c-Kit signaling confers damage-resistance to sweet taste cells upon nerve injury.International journal of oral science · 2025Article
- Pig Taste Cell-derived Organoids Synthesize Insulin.Endocrinology · 2025Article
- Gustatory-neuron-supplied R-spondin-2 is required for taste bud replenishment.Stem cell reports · 2025Article
- Organoid in dentistry: Models for oral biology and disease.Journal of dental sciences · 2025Review
- Circadian clock-gated cell renewal controls time-dependent changes in taste sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Potential Implications of Organoids in Dental Research.Frontiers in dentistry · 2025Review
- Nutrient Sensing by Lingual G-Protein-Coupled Taste Receptors.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Organoids in the oral and maxillofacial region: present and future.International journal of oral science · 2024Review
- A Decade of Organoid Research: Progress and Challenges in the Field of Organoid Technology.ACS omega · 2024Review
- Reassessing the genetic lineage tracing of lingualAnimal cells and systems · 2024Article
- Gastruloid optimization.Emerging topics in life sciences · 2023Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Combination of untargeted and targeted proteomics for secretome analysis of L-WRN cells.Analytical and bioanalytical chemistry · 2023Article
- Cocktail Formula and Application Prospects for Oral and Maxillofacial Organoids.Tissue engineering and regenerative medicine · 2022Review
- Advances of Engineered Hydrogel Organoids within the Stem Cell Field: A Systematic Review.Gels (Basel, Switzerland) · 2022Review
- The sense of taste: Development, regeneration, and dysfunction.WIREs mechanisms of disease · 2022Review
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
Abstract
Leucine-rich repeat-containing G-protein coupled receptor 5-expressing (Lgr5(+)) cells have been identified as stem/progenitor cells in the circumvallate papillae, and single cultured Lgr5(+) cells give rise to taste cells. Here we use circumvallate papilla tissue to establish a three-dimensional culture system (taste bud organoids) that develops phenotypic characteristics similar to native tissue, including a multilayered epithelium containing stem/progenitor in the outer layers and taste cells in the inner layers. Furthermore, characterization of the cell cycle of the taste bud progenitor niche reveals striking dynamics of taste bud development and regeneration. Using this taste bud organoid culture system and FUCCI2 transgenic mice, we identify the stem/progenitor cells have at least 5 distinct cell cycle populations by tracking within 24-hour synchronized oscillations of proliferation. Additionally, we demonstrate that stem/progenitor cells have motility to form taste bud organoids. Taste bud organoids provides a system for elucidating mechanisms of taste signaling, disease modeling, and taste tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.