ArticleJournal of neurotrauma2016
Norepinephrine Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis after Traumatic Brain Injury via Blockade of ERK MAPK and IL-6 in Juvenile Pigs.
Article in Journal of neurotrauma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Article
- Regulation of the Cerebral Circulation During Development.Comprehensive Physiology · 2021Article
- Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats.International journal of molecular sciences · 2021Article
- Novel Synthetic and Natural Therapies for Traumatic Brain Injury.Current neuropharmacology · 2021Review
- Compromised Dynamic Cerebral Autoregulation in Patients With Central Disorders of Hypersomnolence.Frontiers in neurology · 2021Article
- Improving Understanding and Outcomes of Traumatic Brain Injury Using Bidirectional Translational Research.Journal of neurotrauma · 2020Review
- The cerebrovascular response to norepinephrine: A scoping systematic review of the animal and human literature.Pharmacology research & perspectives · 2020Article
- Central Noradrenergic Agonists in the Treatment of Ischemic Stroke-an Overview.Translational stroke research · 2020Review
- Cerebral Perfusion Pressure Directed-Therapy Modulates Cardiac Dysfunction After Traumatic Brain Injury to Influence Cerebral Autoregulation in Pigs.Neurocritical care · 2019Article
- Translational approach towards determining the role of cerebral autoregulation in outcome after traumatic brain injury.Experimental neurology · 2019Review
- Sex differences in pediatric traumatic brain injury.Experimental neurology · 2019Review
- Coenzyme Q10 Protects Astrocytes from Ultraviolet B-Induced Damage Through Inhibition of ERK 1/2 Pathway Overexpression.Neurochemical research · 2019Article
- Inhaled Nitric Oxide Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis After Traumatic Brain Injury Through Inhibition of ET-1, ERK MAPK and IL-6 Upregulation in Pigs.Neurocritical care · 2019Article
- Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK.Translational stroke research · 2019Article
- Synergistic Inhibition of ERK1/2 and JNK, Not p38, Phosphorylation Ameliorates Neuronal Damages After Traumatic Brain Injury.Molecular neurobiology · 2019Article
- The potential roles of dopamine in traumatic brain injury: a preclinical and clinical update.American journal of translational research · 2019Review
- Antioxidant Melatonin: Potential Functions in Improving Cerebral Autoregulation After Subarachnoid Hemorrhage.Frontiers in physiology · 2018Review
- Temporal Course of Cerebral Autoregulation in Patients With Narcolepsy Type 1: Two Case Reports.Frontiers in neurology · 2018Article
- K channel impairment determines sex and age differences in epinephrine-mediated outcomes after brain injury.Journal of neuroscience research · 2017Article
Corrections and comments
- Retraction · 2022-04-29Author Unresponsive · Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · · William Armstead has ORI finding of misconduct; see https://ori.hhs.gov/content/case-summary-armstead-william-m
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- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Traumatic brain injury (TBI) contributes to morbidity in children, and boys are disproportionately represented. Cerebral autoregulation is impaired after TBI, contributing to poor outcome. Cerebral perfusion pressure (CPP) is often normalized by use of vasoactive agents to increase mean arterial pressure (MAP). In prior studies of 1- to 5-day-old newborn piglets, we observed that norepinephrine (NE) preferentially protected cerebral autoregulation and prevented hippocampal necrosis in females but not males after fluid percussion injury (FPI). The ERK isoform of mitogen activated protein kinase (MAPK) produces hemodynamic impairment after FPI, but less is known about the role of the cytokine interleukin-6 (IL-6). We investigated whether NE protects autoregulation and limits histopathology after FPI in older juvenile (4-week-old) pigs and the role of ERK and IL-6 in that outcome by sex. Results show that NE significantly protects autoregulation and prevents reduction in cerebral blood flow (CBF) in both male and female juvenile pigs after FPI; co-administration of the ERK antagonist U 0126 with NE fully protects both indices of outcome. Papaverine induced dilation was unchanged by FPI and NE. NE blunted ERK MAPK and IL-6 upregulation in both males and females after FPI. NE attenuated loss of neurons in CA1 and CA3 hippocampus of males and females after FPI. These data indicate that NE protects autoregulation and limits hippocampal neuronal cell necrosis via blockade of ERK and IL-6 after FPI in both male and female juvenile pigs. These data suggest that use of NE to improve outcome after TBI is both sex and age dependent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.