ArticleNature communications2015
Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Optical focusing into scattering media via iterative time reversal guided by absorption nonlinearity.Nature communications · 2025Article
- An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo.Nature communications · 2024Article
- Single-shot digital optical fluorescence phase conjugation through forward multiple-scattering samples.Science advances · 2024Article
- Performance enhancement in wavefront shaping of multiply scattered light: a review.Journal of biomedical optics · 2024Review
- Wavefront shaping improves the transparency of the scattering media: a review.Journal of biomedical optics · 2024Review
- Toward Tunable Protein-Driven Hydrogel Lens.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Wavefront shaping: A versatile tool to conquer multiple scattering in multidisciplinary fields.Innovation (Cambridge (Mass.)) · 2022Review
- Ultrasound-Responsive Systems as Components for Smart Materials.Chemical reviews · 2022Review
- Focusing light into scattering media with ultrasound-induced field perturbation.Light, science & applications · 2021Article
- Single-shot time-reversed optical focusing into and through scattering media.ACS photonics · 2020Article
- Improvement of light penetration in biological tissue using an ultrasound-induced heating tunnel.Scientific reports · 2020Article
- Fighting against fast speckle decorrelation for light focusing inside live tissue by photon frequency shifting.ACS photonics · 2020Article
- Focusing light inside live tissue using reversibly switchable bacterial phytochrome as a genetically encoded photochromic guide star.Science advances · 2019Article
- Photoacoustic Wavefront Shaping with High Signal to Noise Ratio for Light Focusing Through Scattering Media.Scientific reports · 2019Article
- High-speed alignment optimization of digital optical phase conjugation systems based on autocovariance analysis in conjunction with orthonormal rectangular polynomials.Journal of biomedical optics · 2018Article
- The State of the NIH BRAIN Initiative.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Time-reversed magnetically controlled perturbation (TRMCP) optical focusing inside scattering media.Scientific reports · 2018Article
- Dopaminergic dysfunction in neurodevelopmental disorders: recent advances and synergistic technologies to aid basic research.Current opinion in neurobiology · 2018Review
- Deep tissue optical focusing and optogenetic modulation with time-reversed ultrasonically encoded light.Science advances · 2017Article
- High-speed single-shot optical focusing through dynamic scattering media with full-phase wavefront shaping.Applied physics letters · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Focusing light inside scattering media in a freely addressable fashion is challenging, as the wavefront of the scattered light is highly disordered. Recently developed ultrasound-guided wavefront shaping methods are addressing this challenge, albeit with relatively low modulation efficiency and resolution limitations. In this paper, we present a new technique, time-reversed ultrasound microbubble encoded (TRUME) optical focusing, which can focus light with improved efficiency and sub-ultrasound wavelength resolution. This method ultrasonically destroys microbubbles, and measures the wavefront change to compute and render a suitable time-reversed wavefront solution for focusing. We demonstrate that the TRUME technique can create an optical focus at the site of bubble destruction with a size of ∼2 μm. We further demonstrate a twofold enhancement in addressable focus resolution in a microbubble aggregate target by exploiting the nonlinear pressure-to-destruction response of the microbubbles. The reported technique provides a deep tissue-focusing solution with high efficiency, resolution, and specificity.
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Registered trials
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