ArticleBrain structure & function2016
Fornix deep brain stimulation enhances acetylcholine levels in the hippocampus.
Article in Brain structure & function, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders.Translational psychiatry · 2024Pooled it
- Cognitive outcomes of deep brain stimulation depend on age and hippocampal connectivity in Parkinson's and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Neurotransmitters' white matter mapping unveils the neurochemical fingerprints of stroke.Nature communications · 2025Article
- Cortical acetylcholine response to deep brain stimulation of the basal forebrain in mice.Journal of neurophysiology · 2025Article
- Cortical Acetylcholine Response to Deep Brain Stimulation of the Basal Forebrain.bioRxiv : the preprint server for biology · 2024Article
- Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease.Heliyon · 2024Review
- Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms.Aging and disease · 2023Article
- Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition.Scientific reports · 2022Article
- Controlling Alzheimer's Disease Through the Deep Brain Stimulation to Thalamic Relay Cells.Frontiers in computational neuroscience · 2021Article
- Prelimbic Cortical Stimulation Improves Spatial Memory Through Distinct Patterns of Hippocampal Gene Expression in Aged Rats.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
- The effect of fornix deep brain stimulation in brain diseases.Cellular and molecular life sciences : CMLS · 2020Review
- Modulation of Human Memory by Deep Brain Stimulation of the Entorhinal-Hippocampal Circuitry.Neuron · 2020Review
- The Paradoxical Effect of Deep Brain Stimulation on Memory.Aging and disease · 2020Review
- A circuit view of deep brain stimulation in Alzheimer's disease and the possible mechanisms.Molecular neurodegeneration · 2019Review
- Deep brain stimulation: potential for neuroprotection.Annals of clinical and translational neurology · 2019Review
- Opening the debate on deep brain stimulation for Alzheimer disease - a critical evaluation of rationale, shortcomings, and ethical justification.BMC medical ethics · 2018Article
- Acute Fornix Deep Brain Stimulation Improves Hippocampal Glucose Metabolism in Aged Mice.Chinese medical journal · 2018Article
- Deep brain stimulation for Alzheimer's Disease: An update.Surgical neurology international · 2018Review
- Fornix deep brain stimulation induced long-term spatial memory independent of hippocampal neurogenesis.Brain structure & function · 2017Article
- Forniceal deep brain stimulation in a mouse model of Rett syndrome increases neurogenesis and hippocampal memory beyond the treatment period.Brain stimulationArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation (DBS) of the fornix has gained interest as a potential therapy for advanced treatment-resistant dementia, yet the mechanism of action remains widely unknown. Previously, we have reported beneficial memory effects of fornix DBS in a scopolamine-induced rat model of dementia, which is dependent on various brain structures including hippocampus. To elucidate mechanisms of action of fornix DBS with regard to memory restoration, we performed c-Fos immunohistochemistry in the hippocampus. We found that fornix DBS induced a selective activation of cells in the CA1 and CA3 subfields of the dorsal hippocampus. In addition, hippocampal neurotransmitter levels were measured using microdialysis before, during and after 60 min of fornix DBS in a next experiment. We observed a substantial increase in the levels of extracellular hippocampal acetylcholine, which peaked 20 min after stimulus onset. Interestingly, hippocampal glutamate levels did not change compared to baseline. Therefore, our findings provide first experimental evidence that fornix DBS activates the hippocampus and induces the release of acetylcholine in this region.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.