ArticleThe journal of pain2016
Total Western Diet Alters Mechanical and Thermal Sensitivity and Prolongs Hypersensitivity Following Complete Freund's Adjuvant in Mice.
Article in The journal of pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The Effectiveness of Intermittent Fasting, Time Restricted Feeding, Caloric Restriction, a Ketogenic Diet and the Mediterranean Diet as Part of the Treatment Plan to Improve Health and Chronic Musculoskeletal Pain: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Obesity and pain: a systematic review.International journal of obesity (2005) · 2020Pooled it
- The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis.Pain medicine (Malden, Mass.) · 2020Trial
- Intermittent fasting alleviates hyperalgesia in ovariectomized mice via gut microbiota remodeling.NPJ biofilms and microbiomes · 2026Article
- Review
- Investigation of the Impact of a Low-Carbohydrate Diet on The Chronic Pain Experience Among Adults with an Acquired Limb Loss: A Pilot Study.Journal of pain research · 2025Article
- The effect of a low-carbohydrate diet on evoked pain and quality of life in Non-Hispanic black women with knee osteoarthritis: a pilot study.BMC musculoskeletal disorders · 2024Article
- Low-Carbohydrate High-Fat Diet: A SWOC Analysis.Metabolites · 2022Review
- High-fat diet causes mechanical allodynia in the absence of injury or diabetic pathology.Scientific reports · 2022Article
- Dietary Inflammatory Index (DII) is Associated with Movement-Evoked Pain Severity in Adults with Chronic Low Back Pain: Sociodemographic Differences.The journal of pain · 2022Article
- The relationship between dietary acid load and intensity of musculoskeletal pain condition: A population-based study.Food science & nutrition · 2022Article
- Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents.Scientific reports · 2021Article
- Poor diet quality is associated with self-reported knee pain in community-dwelling women aged 50 years and older.PloS one · 2021Article
- Interrelationship of Neurogenic Obesity and Chronic Neuropathic Pain in Persons With Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2021Review
- Article
- Evaluating analgesic efficacy and administration route following craniotomy in mice using the grimace scale.Scientific reports · 2019Article
- High-fat diet and post-operative pain: Why the hospital cafeteria may matter.Brain, behavior, and immunity · 2018Article
- Article
- Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?Neuroscience letters · 2018Article
- Peripheral Leptin Signaling Mediates Formalin-Induced Nociception.Neuroscience bulletin · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledObesity and chronic pain are often comorbid and their rates are increasing. It is unknown whether increased pain is caused by greater weight or poor diet quality or both. Therefore, we utilized a Total Western Diet (TWD) to investigate the functional and physiologic consequences of nutritionally poor diet in mice. For 13 weeks on the commercially available TWD, based on the National Health and Nutrition Examination Survey, thresholds of TWD-fed mice significantly increased in both thermal and mechanical tests. Quantitative magnetic resonance imaging revealed a significant increase in fat mass with a concomitant decrease in lean mass in the TWD-fed mice. In addition, there were significant increases in levels of serum leptin and inflammatory cytokines. After chronic pain induction using complete Freund's adjuvant, hypersensitivity was more pronounced and significantly prolonged in the TWD-fed mice. Therefore, prolonged exposure to poor diet quality resulted in altered acute nociceptive sensitivity, systemic inflammation, and persistent pain after inflammatory pain induction. PERSPECTIVE: These results highlight the negative effects of poor diet quality with respect to recovery from hypersensitivity and susceptibility to chronic pain. A complete understanding of the impact of diet can aid in treatment and recovery dynamics in human clinical patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.