Evidence map›Paper›PMID 26597154›Full record

ArticleJournal of the American Heart Association2015

N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives.

Andrea Vilar-Bergua, Iolanda Riba-Llena, Valerie Vanhooren, Sylviane Dewaele, Claude Libert, Anna Penalba, Joan Montaner, Pilar Delgado

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Immunomodulatory role of glycoRNAs in the brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  4. High-Throughput Glycomic Methods.Chemical reviews · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Andrea Vilar-BerguaNeurovascular Research Laboratory, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (A.V.B., I.R.L., A.P., J.M., P.D.).
Iolanda Riba-LlenaNeurovascular Research Laboratory, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (A.V.B., I.R.L., A.P., J.M., P.D.).
Valerie VanhoorenInflammation Research Center, UGent-VIB Research Building FSVM, Ghent, Belgium (V.V., S.D., C.L.) Biomedical Molecular Biology Department, Ghent University, Ghent, Belgium (V.V., S.D., C.L.).
Sylviane DewaeleInflammation Research Center, UGent-VIB Research Building FSVM, Ghent, Belgium (V.V., S.D., C.L.) Biomedical Molecular Biology Department, Ghent University, Ghent, Belgium (V.V., S.D., C.L.).
Claude LibertInflammation Research Center, UGent-VIB Research Building FSVM, Ghent, Belgium (V.V., S.D., C.L.) Biomedical Molecular Biology Department, Ghent University, Ghent, Belgium (V.V., S.D., C.L.).
Anna PenalbaNeurovascular Research Laboratory, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (A.V.B., I.R.L., A.P., J.M., P.D.).
Joan MontanerNeurovascular Research Laboratory, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (A.V.B., I.R.L., A.P., J.M., P.D.) Stroke Unit, Neurology Department, Vall d'Hebron Hospital, Barcelona, Spain (J.M.).
Pilar DelgadoNeurovascular Research Laboratory, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (A.V.B., I.R.L., A.P., J.M., P.D.).
Vall d'Hebron Institut de Recerca · ESGhent University · BEUniversitat Autònoma de Barcelona · ESVIB-UGent Center for Inflammation Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSilent brain infarcts (SBIs) are highly prevalent in the aged population and relate to the occurrence of further stroke and dementia. Serum N-glycome levels have been previously associated with aging and they might be related as well to the presence of SBIs and age-related white matter hyperintensities. METHODS AND

resultsWe determined the serum N-glycome profile in a cohort study comprising 972 subjects and evaluated the relationship between N-glycome levels and the presence and number of SBIs and with age-related white matter hyperintensities grades, assessed by brain magnetic resonance imaging. Decreasing concentrations of bigalacto core-α-1,6-fucosylated biantennary glycan and increasing concentrations of branching α-1,3-fucosylated triantennary glycan remained as independent predictors of SBIs (odds ratio 0.4, 95% CI 0.3-0.7 and odds ratio 1.8, 95% CI 1-3.2, respectively), after controlling for the presence of age and classic vascular risk factors. A similar pattern was found to be related to an increasing number of SBIs and white matter hyperintensities grade.

conclusionsN-glycome levels might be potentially useful as biomarkers for the presence of silent cerebrovascular disease.

Indexed as

AgedAsymptomatic DiseasesBiomarkersBrain InfarctionChi-Square DistributionCohort StudiesFemaleGlycomicsHumansHypertensionLeukoencephalopathiesLinear ModelsLogistic ModelsMagnetic Resonance ImagingMaleMiddle AgedBiomarkersPolysaccharidesagingbiomarkerN‐glycome profilesilent brain infarctwhite matter hyperintensities

Identifiers

PMID26597154
PMCPMC4845233
OpenAlexW2174840434

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.