Evidence map›Paper›PMID 26597109›Full record

ReviewMolecular oncology2015

Intracellular antigens as targets for antibody based immunotherapy of malignant diseases.

Yangyang Wang, Xinhui Wang, Cristina R Ferrone, Joseph H Schwab, Soldano Ferrone

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. B7-H3 targeted antibody-based immunotherapy of malignant diseases.Expert opinion on biological therapy · 2021
    Article
  7. Review
  8. Review
  9. Article
  10. Bioactive Nanoparticles for Cancer Immunotherapy.International journal of molecular sciences · 2018
    Review
  11. Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yangyang WangDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
Xinhui WangDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
Cristina R FerroneDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
Joseph H SchwabDepartment of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
Soldano FerroneDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States; Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States. Electronic address: sferrone@mgh.harvard.edu.
Massachusetts General Hospital · USHarvard University · US

Funding

Grp94 targeted therapy for pancreatic ductal adenocarcinomaR21CA164756 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FERRONE, CRISTINA R., FERRONE, SOLDANO · 2013 to 2014
$409k
Improving Radiation Therapy For Pancreatic CancerR21CA181851 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, XINHUI · 2015 to 2016
$407k
Therapy of pancreatic cancer with 212Pb-labeled B7-H3 specific Ab and LDE225R21CA173120 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUCHSBAUM, DONALD J, FERRONE, SOLDANO · 2014 to 2015
$388k
HSP based combinatorial immunotherapy in triple negative breast cancerR03CA175957 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FERRONE, SOLDANO · 2014 to 2015
$170k
NCI NIH HHS 1R03CA175957NCI NIH HHS 1R21CA173120NCI NIH HHS R03 CA175957NCI NIH HHS R21 CA164756NCI NIH HHS R21 CA173120NCI NIH HHS R21 CA181851
6 · The paper itself

Abstract

This review discusses the potential use of intracellular tumor antigens as targets of antibody-based immunotherapy for the treatment of solid tumors. In addition, it describes the characteristics of the intracellular tumor antigens targeted with antibodies which have been described in the literature and have been identified in the authors' laboratory. Finally, the mechanism underlying the trafficking of the intracellular tumor antigens to the plasma membrane of tumor cells are reviewed.

Indexed as

ImmunotherapyAnimalsAntigens, NeoplasmEndoplasmic Reticulum Chaperone BiPHumansNeoplasmsAntigens, NeoplasmEndoplasmic Reticulum Chaperone BiPHSPA5 protein, humanGrp78Grp94Hsp70Intracellular tumor antigenMonoclonal antibodiesPRL-3

Identifiers

PMID26597109
PMCPMC5528737
OpenAlexW1821051263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.