ArticleScientific reports2015
Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Tissue-specific mutation of pink-1 jointly induces intestinal dysfunction and contributes to dopaminergic neuron degeneration.NPJ Parkinson's disease · 2026Article
- Excitatory GABA receptors shape locomotor circuit organization in C. elegans.Scientific reports · 2026Article
- CPD-1 can compensate for EGL-21 to process neuropeptides.microPublication biology · 2026Article
- Nicotine induces abnormal motor coupling through sensitization of a mechanosensory circuit in Caenorhabditis elegans.PLoS biology · 2025Article
- Glia in Invertebrate Models: Insights from Caenorhabditis elegans.Advances in neurobiology · 2024Review
- A single neuron in C. elegans orchestrates multiple motor outputs through parallel modes of transmission.Current biology : CB · 2023Article
- The head mesodermal cell couples FMRFamide neuropeptide signaling with rhythmic muscle contraction in C. elegans.Nature communications · 2023Article
- A single neuron inbioRxiv : the preprint server for biology · 2023Article
- Inferences of glia-mediated control in Caenorhabditis elegans.Journal of neuroscience research · 2021Article
- Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling ineLife · 2020Article
- Three-dimensional virtual refocusing of fluorescence microscopy images using deep learning.Nature methods · 2019Article
- Interneurons Regulate Locomotion Quiescence via Cyclic Adenosine Monophosphate Signaling During Stress-Induced Sleep inGenetics · 2019Article
- CamicroPublication biology · 2019Article
- The HSN egg-laying command neurons regulate the defecation motor program inmicroPublication biology · 2019Article
- Ratiometric Calcium Imaging of Individual Neurons in Behaving Caenorhabditis Elegans.Journal of visualized experiments : JoVE · 2018Article
- Electrophysiology of the rhythmic defecation program in nematode Heterorhabditis megidis.Scientific reports · 2017Article
- Microfluidic platform with spatiotemporally controlled micro-environment for studying long-term C. elegans developmental arrests.Lab on a chip · 2017Article
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4 authors.
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Abstract
Distinct motor programs can be coupled to refine the repertoire of behavior dynamics. However, mechanisms underlying such coupling are poorly understood. The defecation motor program (DMP) of C. elegans is composed of a succession of body contraction and expulsion steps, performed repeatedly with a period of 50-60 sec. We show that recurring patterns of directed locomotion are executed in tandem with, co-reset, and co-terminate with the DMP cycle. Calcium waves in the intestine and proton signaling were shown to regulate the DMP. We found that genetic manipulations affecting these calcium dynamics regulated the corresponding patterns of directed locomotion. Moreover, we observed the initiation of a recurring locomotion pattern 10 seconds prior to the posterior body contraction, suggesting that the synchronized motor program may initiate prior to the DMP. This study links two multi-step motor programs executed by C. elegans in synchrony, utilizing non-neuronal tissue to drive directed locomotion.
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