ArticleScientific reports2015
Amelanism in the corn snake is associated with the insertion of an LTR-retrotransposon in the OCA2 gene.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 50 citations in OpenAlex.
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- Somitic positional information guides self-organized patterning of snake scales.Science advances · 2023Article
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- A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius).PloS one · 2022Article
- Two Reference-Quality Sea Snake Genomes Reveal Their Divergent Evolution of Adaptive Traits and Venom Systems.Molecular biology and evolution · 2021Article
- Genome mapping of aProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The genomics of coloration provides insights into adaptive evolution.Nature reviews. Genetics · 2020Review
- Genomic Analysis of the Only Blind Cichlid Reveals Extensive Inactivation in Eye and Pigment Formation Genes.Genome biology and evolution · 2020Article
- Gephebase, a database of genotype-phenotype relationships for natural and domesticated variation in Eukaryotes.Nucleic acids research · 2020Article
- Repeat domain-associated O-glycans govern PMEL fibrillar sheet architecture.Scientific reports · 2019Article
- Comparative skin transcriptome of two Oujiang color common carp (Cyprinus carpio var. color) varieties.Fish physiology and biochemistry · 2019Article
- Making sense of genomic islands of differentiation in light of speciation.Nature reviews. Genetics · 2017Review
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6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The corn snake (Pantherophis guttatus) is a new model species particularly appropriate for investigating the processes generating colours in reptiles because numerous colour and pattern mutants have been isolated in the last five decades. Using our captive-bred colony of corn snakes, transcriptomic and genomic next-generation sequencing, exome assembly, and genotyping of SNPs in multiple families, we delimit the genomic interval bearing the causal mutation of amelanism, the oldest colour variant observed in that species. Proceeding with sequencing the candidate gene OCA2 in the uncovered genomic interval, we identify that the insertion of an LTR-retrotransposon in its 11(th) intron results in a considerable truncation of the p protein and likely constitutes the causal mutation of amelanism in corn snakes. As amelanistic snakes exhibit white, instead of black, borders around an otherwise normal pattern of dorsal orange saddles and lateral blotches, our results indicate that melanocytes lacking melanin are able to participate to the normal patterning of other colours in the skin. In combination with research in the zebrafish, this work opens the perspective of using corn snake colour and pattern variants to investigate the generative processes of skin colour patterning shared among major vertebrate lineages.
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