ReviewChromosoma2016
Hox genes, evo-devo, and the case of the ftz gene.
Review in Chromosoma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Genome-Wide Analysis ofPlants (Basel, Switzerland) · 2025Article
- A conserved sequence that sparked the field of evo-devo.Developmental biology · 2025Review
- Expression of posterior Hox genes and opisthosomal appendage development in a mygalomorph spider.Development genes and evolution · 2023Article
- Annotation of Hox cluster and Hox cofactor genes in the Asian citrus psyllid,GigaByte (Hong Kong, China) · 2022Article
- Patterning, From Conifers to Consciousness: Turing's Theory and Order From Fluctuations.Frontiers in cell and developmental biology · 2022Review
- Panarthropod tiptop/teashirt and spalt orthologs and their potential role as "trunk"-selector genes.EvoDevo · 2021Article
- Article
- RNAi-Based Functional Genomics in Hemiptera.Insects · 2020Review
- Article
- Integrated transcriptomics reveals master regulators of lung adenocarcinoma and novel repositioning of drug candidates.Cancer medicine · 2019Article
- Seeing is believing: the Bicoid protein reveals its path.Hereditas · 2018Article
- Conservation and variation in pair-rule gene expression and function in the intermediate-germ beetleDevelopment (Cambridge, England) · 2017Article
- Shared sociogenetic basis of honey bee behavior and human risk for autism.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Polycomb and trithorax opposition in development and disease.Wiley interdisciplinary reviews. Developmental biology · 2016Review
- Homeodomain proteins: an update.Chromosoma · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The discovery of the broad conservation of embryonic regulatory genes across animal phyla, launched by the cloning of homeotic genes in the 1980s, was a founding event in the field of evolutionary developmental biology (evo-devo). While it had long been known that fundamental cellular processes, commonly referred to as housekeeping functions, are shared by animals and plants across the planet-processes such as the storage of information in genomic DNA, transcription, translation and the machinery for these processes, universal codon usage, and metabolic enzymes-Hox genes were different: mutations in these genes caused "bizarre" homeotic transformations of insect body parts that were certainly interesting but were expected to be idiosyncratic. The isolation of the genes responsible for these bizarre phenotypes turned out to be highly conserved Hox genes that play roles in embryonic patterning throughout Metazoa. How Hox genes have changed to promote the development of diverse body plans remains a central issue of the field of evo-devo today. For this Memorial article series, I review events around the discovery of the broad evolutionary conservation of Hox genes and the impact of this discovery on the field of developmental biology. I highlight studies carried out in Walter Gehring's lab and by former lab members that have continued to push the field forward, raising new questions and forging new approaches to understand the evolution of developmental mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.