ArticleScientific reports2015
Buckling of Microtubules on a 2D Elastic Medium.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Growth directions and stiffness across cell layers determine whether tissues stay smooth or buckle.Current biology : CB · 2026Article
- Kinesin-Induced Buckling Reveals the Limits of Microtubule Self-Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Molecular resilience of neurons to repetitive mechanical compression.Communications biology · 2026Article
- Article
- Active spiralling of microtubules driven by kinesin motors.Scientific reports · 2025Article
- Nonequilibrium Self-Assembly of Microtubules Through Stepwise Sequential Interactions of DNA.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Global alignment and local curvature of microtubules in mouse fibroblasts are robust against perturbations of vimentin and actin.Soft matter · 2025Article
- Mechanical fatigue in microtubules.Scientific reports · 2024Article
- A mechanical transition from tension to buckling underlies the jigsaw puzzle shape morphogenesis of histoblasts in the Drosophila epidermis.PLoS biology · 2024Article
- Can repetitive mechanical motion cause structural damage to axons?Frontiers in molecular neuroscience · 2024Review
- Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.Scientific reports · 2023Article
- Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment.Communications biology · 2023Review
- A minimal model of elastic instabilities in biological filament bundles.Journal of the Royal Society, Interface · 2022Article
- Cytoskeletal Tensegrity in Microgravity.Life (Basel, Switzerland) · 2021Review
- Are microtubules tension sensors?Nature communications · 2019Review
- Kinesin motor density and dynamics in gliding microtubule motility.Scientific reports · 2019Article
- Control of swarming of molecular robots.Scientific reports · 2018Article
- Role of extrinsic mechanical force in the development of the RA-I tactile mechanoreceptor.Scientific reports · 2018Article
- DNA-assisted swarm control in a biomolecular motor system.Nature communications · 2018Article
- Characterization of microtubule buckling in living cells.European biophysics journal : EBJ · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have demonstrated compression stress induced mechanical deformation of microtubules (MTs) on a two-dimensional elastic medium and investigated the role of compression strain, strain rate, and a MT-associated protein in the deformation of MTs. We show that MTs, supported on a two-dimensional substrate by a MT-associated protein kinesin, undergo buckling when they are subjected to compression stress. Compression strain strongly affects the extent of buckling, although compression rate has no substantial effect on the buckling of MTs. Most importantly, the density of kinesin is found to play the key role in determining the buckling mode of MTs. We have made a comparison between our experimental results and the 'elastic foundation model' that theoretically predicts the buckling behavior of MTs and its connection to MT-associated proteins. Taking into consideration the role of kinesin in altering the mechanical property of MTs, we are able to explain the buckling behavior of MTs by the elastic foundation model. This work will help understand the buckling mechanism of MTs and its connection to MT-associated proteins or surrounding medium, and consequently will aid in obtaining a meticulous scenario of the compression stress induced deformation of MTs in cells.
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