Evidence map›Paper›PMID 26596804›Full record

ReviewCardiac electrophysiology clinics2015

Cellular and Molecular Aspects of Dyssynchrony and Resynchronization.

Jonathan A Kirk, David A Kass

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiac electrophysiology clinics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Concepts of Cardiac Dyssynchrony and Dynamic Approach.Diagnostics (Basel, Switzerland) · 2024
    Review
  3. Conduction System Pacing for Cardiac Resynchronization Therapy.Journal of cardiovascular development and disease · 2023
    Review
  4. A perspective on Notch signalling in progression and arrhythmogenesis in familial hypertrophic and dilated cardiomyopathies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  5. Relationships between electrical and mechanical dyssynchrony in patients with left bundle branch block and healthy controls.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jonathan A KirkDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Ross Research Building, Room 858, 720 Rutland Avenue, Baltimore, MD 21205, USA. Electronic address: jkirk2@luc.edu.
David A KassDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Ross Research Building, Room 858, 720 Rutland Avenue, Baltimore, MD 21205, USA.

Funding

Pathobiology of Cardiac Dyssynchrony &ResynchronizationP01HL077180 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI VAN EYK, JENNIFER E · 2004 to 2014
$22.8M
Mechanisms of Right Ventricular Dysfunction in Scleroderma-associated PAHR01HL114910 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASSOUN, PAUL M. · 2012 to 2023
$6.2M
A new post-translational modification, citrullination, changes in heart failureR21HL112586 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI VAN EYK, JENNIFER E · 2012 to 2013
$436k
NHLBI NIH HHS HHSN268201000032CNHLBI NIH HHS HL-112586NHLBI NIH HHS HL-114910NHLBI NIH HHS P01 HL077180NHLBI NIH HHS P01-HL077180NHLBI NIH HHS R01 HL114910NHLBI NIH HHS R21 HL112586
6 · The paper itself

Abstract

Dyssynchronous contraction of the ventricle significantly worsens morbidity and mortality in patients with heart failure (HF). Approximately one-third of patients with HF have cardiac dyssynchrony and are candidates for cardiac resynchronization therapy (CRT). The initial understanding of dyssynchrony and CRT was in terms of global mechanics and hemodynamics, but lack of clinical benefit in a sizable subgroup of recipients who appear otherwise appropriate has challenged this paradigm. This article reviews current understanding of these cellular and subcellular mechanisms, arguing that these aspects are key to improving CRT use, as well as translating its benefits to a wider HF population.

Indexed as

Models, CardiovascularMuscle CellsMyocardial ContractionAnimalsCardiac Resynchronization TherapyExcitation Contraction CouplingHeart Conduction SystemHeart FailureHumansVentricular Dysfunction, LeftAnimal modelsCardiac resynchronization therapyDyssynchronyMyocyteMyofilament

Identifiers

PMID26596804
PMCPMC4660268

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.