ArticleBMC genomics2015
Genetic associations and shared environmental effects on the skin microbiome of Korean twins.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 76 citations in OpenAlex.
- Dysbiosis in the Pathogenesis of Atopic Dermatitis.The Journal of dermatology · 2026Review
- The human skin microbiome: factors affecting individuality and application in forensic investigations.International journal of legal medicine · 2026Review
- Pro-inflammatory microbiota mediates the effect of host risk genes in Crohn's disease.Frontiers in microbiology · 2026Review
- Article
- Profiling skin microbiota in an underrepresented population: Indonesian children with atopic dermatitis and controls.Frontiers in medicine · 2026Article
- The human skin microbiome in health.Journal of the American Academy of Dermatology · 2025Review
- The Role of Skin Dysbiosis and Quorum Sensing in Atopic Dermatitis.JID innovations : skin science from molecules to population health · 2025Review
- Evaluation of skin cancer prevention properties of probiotics.Genes & nutrition · 2025Review
- Uropygial gland microbiota of nearctic-neotropical migrants vary with season and migration distance.Animal microbiome · 2025Article
- Skin microbiota variation in Indian families.PeerJ · 2025Article
- The sticky situation of human skin.Journal of biosciences · 2025Article
- Estimates of microbiome heritability across hosts.Nature microbiology · 2024Review
- Association Between Scalp Microbiota Imbalance, Disease Severity, and Systemic Inflammatory Markers in Alopecia Areata.Dermatology and therapy · 2024Article
- Aging-Induced Changes inMicroorganisms · 2024Article
- Article
- Facial Skin Microbiome: Aging-Related Changes and Exploratory Functional Associations with Host Genetic Factors, a Pilot Study.Biomedicines · 2023Article
- Pathogenic role of the staphylococcal accessory gene regulator quorum sensing system in atopic dermatitis.Frontiers in cellular and infection microbiology · 2023Review
- Influence of Sex on the Microbiota of the Human Face.Microorganisms · 2022Article
- Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.Nature communications · 2022Article
- Towards standardized and reproducible research in skin microbiomes.Environmental microbiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe skin is the outermost layer of the human body and one of the key sites for host-microbe interactions. Both environmental and host genetic factors influence microbial communities in distinct anatomical niches, but little is known about their interplay in shaping the skin microbiome. Here, we investigate the heritable components of the skin microbiome and their association with host genetic factors.
resultsBased on our analysis of the microbiota from 45 individuals including monozygotic and dizygotic twins aged 26-55 years and their mothers, we found that skin microbial diversity was significantly influenced by age and skin pigmentation. Heritability analysis revealed genetic and shared environmental impacts on the skin microbiome. Furthermore, we observed a strong association between the abundance of Corynebacterium jeikeium and single nucleotide polymorphisms (SNPs) in the host FLG gene related to epidermal barrier function.
conclusionThis study reveals an intimate association of the human skin microbiome and host genes, and increases our understanding of the role of human genetic factors in establishing a microbial ecosystem on the body surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.