ArticleMedicina oral, patologia oral y cirugia bucal2016
Evaluation of Xerostomia and salivary flow rate in Hashimoto's Thyroiditis.
Article in Medicina oral, patologia oral y cirugia bucal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Salivary Alterations in Autoimmune Thyroid Diseases: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Impact of TCAs and Gabapentin on Saliva and BMI in Adults With Xerostomia.Journal of oral rehabilitation · 2026Article
- Ultrasonographic Evaluation of Salivary Gland Stiffness in Primary Sjögren's Disease and Idiopathic Xerostomia.Oral diseases · 2026Article
- Anti-M3 Muscarinic Acetylcholine Receptor Autoantibody in the Serum and Saliva of Oral Lichen Planus Patients: A Case-Control Study.Health science reports · 2026Article
- Oral mucosal health in acromegaly: clinical insights and metabolic associations.BMC oral health · 2025Article
- Article
- Dental Pulp Stem Cells for Salivary Gland Regeneration-Where Are We Today?International journal of molecular sciences · 2023Review
- Association between dental caries experience and salivary profile among autoimmune thyroid disease subjects - a cross-sectional comparative study.F1000Research · 2023Article
- Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto's Thyroiditis Patients.Mediators of inflammation · 2021Article
- Enhanced Salivary and General Oxidative Stress in Hashimoto's Thyroiditis Women in Euthyreosis.Journal of clinical medicine · 2020Article
- Estimation of Salivary Parameters among Autoimmune Thyroiditis Patients.Journal of clinical and diagnostic research : JCDR · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOne of the most common causes of hypothyroidism is Hashimoto's Thyroiditis (HT). Early detection of dry mouth is critical in preserving and promoting systemic and oral health. In this study we have assessed, for the first time, salivary function and xerostomia in HT patients who have not been involved with Sjögren's syndrome. MATERIAL AND
methodsHT was diagnosed in 40 patients based on clinical findings and positive anti-thyroid peroxidase antibodies (anti-TPO). Controls, matched by sex, age and body mass index (BMI), and with no history of thyroid disease, were selected. A questionnaire was used for diagnosis of xerostomia. Saliva samples were taken between 8 a.m. and 9 a.m., and at least 2 hours after the last intake of food or drink. The flow rate was calculated in milliliters per minute.
resultsXerostomia was significantly higher in patients with HT. Unstimulated salivary flow rate was significantly lower in the HT group. Stimulated salivary flow rate was lower in HT group, but the difference was not significant.
conclusionsThe patients with HT experienced xerostomia, and their salivary flow rate was diminished. Spitting the saliva then assessing salivary flow rate based on milliliter per minute is non-invasive, fast, and simple for chair-side diagnosis of dry mouth. Autoimmune diseases can be accompanied by salivary gland dysfunction. This may be due to the effect of cytokines in the autoimmune process or because of thyroid hormone dysfunctions.
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